Rtkn rhotekin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rtknprovided by RGD
Full Name: rhotekinprovided by RGD
Primary source: RGD:727874
See related: EnsemblRapid:ENSRNOG00000009022 AllianceGenome:RGD:727874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be active in actomyosin contractile ring. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 67.7), Kidney (RPKM 44.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117198496..117215660)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115640813..115657952)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (114833453..114850705)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rhotekin is required for maintenance and survival of neurons and positively regulates differentiation and neurite outgrowth.
Title: Rhotekin modulates differentiation of cultured neural stem cells to neurons.
SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables GTPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables GTPase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rhotekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415851.2 → NP_001402780.1 rhotekin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q6V7V1, Q6V7V2

UniProtKB/TrEMBL

A6IAK9

Related

ENSRNOP00000032233.3, ENSRNOT00000031964.6
NM_001415852.2 → NP_001402781.1 rhotekin isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6AIK7

Related

ENSRNOP00000092765.1, ENSRNOT00000101909.2
NM_001415853.2 → NP_001402782.1 rhotekin isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

Related

ENSRNOP00000099265.1, ENSRNOT00000124729.1
NM_001415854.2 → NP_001402783.1 rhotekin isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004
NM_184046.3 → NP_908935.1 rhotekin isoform 1

See identical proteins and their annotated locations for NP_908935.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q6V7V1, Q6V7V2

UniProtKB/TrEMBL

A0A8I6G5K4, A6IAK9

Conserved Domains (3) summary

smart00742
Location:23 → 78

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam08174
Location:104 → 257

Anillin; Cell division protein anillin

cl17171
Location:296 → 406

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

117198496..117215660

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285792.1 → XP_063141862.1 rhotekin isoform X5
XM_063285795.1 → XP_063141865.1 rhotekin isoform X7
XM_039107325.2 → XP_038963253.1 rhotekin isoform X4

UniProtKB/TrEMBL

A0A8I6G5K4

Conserved Domains (3) summary

pfam08174
Location:67 → 220

Anillin; Cell division protein anillin

cl00087
Location:1 → 41

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl17171
Location:259 → 369

PH-like; Pleckstrin homology-like domain
XM_063285797.1 → XP_063141867.1 rhotekin isoform X9
XM_063285794.1 → XP_063141864.1 rhotekin isoform X7
XM_063285793.1 → XP_063141863.1 rhotekin isoform X6
XM_063285796.1 → XP_063141866.1 rhotekin isoform X8
XM_008763038.4 → XP_008761260.1 rhotekin isoform X3

See identical proteins and their annotated locations for XP_008761260.1

UniProtKB/TrEMBL

A0A8L2UPK3

Conserved Domains (4) summary

smart00742
Location:80 → 135

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam00169
Location:377 → 455

PH; PH domain

pfam08174
Location:161 → 314

Anillin; Cell division protein anillin

cl17171
Location:353 → 463

PH-like; Pleckstrin homology-like domain
XM_008763037.4 → XP_008761259.1 rhotekin isoform X2

See identical proteins and their annotated locations for XP_008761259.1

UniProtKB/TrEMBL

A0A8L2UPK3

Conserved Domains (4) summary

smart00742
Location:80 → 135

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam00169
Location:307 → 385

PH; PH domain

pfam08174
Location:161 → 244

Anillin; Cell division protein anillin

cl17171
Location:283 → 393

PH-like; Pleckstrin homology-like domain
XM_008763034.4 → XP_008761256.1 rhotekin isoform X1

See identical proteins and their annotated locations for XP_008761256.1

UniProtKB/TrEMBL

A0A8L2UPK3

Related

ENSRNOP00000069449.3, ENSRNOT00000079547.3

Conserved Domains (4) summary

smart00742
Location:80 → 135

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam00169
Location:377 → 455

PH; PH domain

pfam08174
Location:161 → 314

Anillin; Cell division protein anillin

cl17171
Location:353 → 463

PH-like; Pleckstrin homology-like domain