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    Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29738, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnab2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by RGD
    Primary source
    RGD:61828
    See related
    EnsemblRapid:ENSRNOG00000011550 AllianceGenome:RGD:61828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 249.8), Thymus (RPKM 121.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnab2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168182228..168270760, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162899511..162988057, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169570327..169658875, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103139 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene nephrocystin 4 Neighboring gene uncharacterized LOC134479049 Neighboring gene uncharacterized LOC102549399

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels. Alka K, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25066316
    2. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. Ovsepian SV, et al. J Physiol, 2013 Apr 1. PMID 23318870, Free PMC Article
    3. Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4. Accili EA, et al. J Physiol, 1998 Oct 15. PMID 9763623, Free PMC Article
    4. Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6). Xie Z, et al. Chem Biol Interact, 2011 May 30. PMID 21296056, Free PMC Article
    5. Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Tipparaju SM, et al. Biochemistry, 2008 Aug 26. PMID 18672894, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that potassium channel Kvbeta2 inhibitors could serve as tools to decipher the role of Kvbeta2 in vivo and, eventually, inform the development of novel therapeutics.
      Title: New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels.
    2. Article reports a newly identified protein-protein interaction between the PSD-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
      Title: The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
    3. Kvbeta2 catalyzed the NADPH-dependent reduction of several products of oxPAPC
      Title: Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6).
    4. ZIP3 formed dimers with ZIP1-3 and interacted with PKC-zeta and the shaker-type potassium channel subunit Kv beta 2
      Title: ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.
    5. identification of Kvbeta2 substrates and the demonstration that Kvbeta2 is a functional aldo-keto reductase
      Title: Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase.
    6. There is a possibility that the K+ voltage-gated channel function is modulated by its beta-subunit.
      Title: Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in juxtaparanode region of axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pinceau fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel subunit beta-2
    Names
    K(+) channel subunit beta-2
    kv-beta-2
    potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2
    potassium channel, voltage gated subfamily A regulatory beta subunit 2
    potassium voltage-gated channel, shaker-related subfamily, beta member 2
    NP_059000.1
    XP_017448703.1
    XP_017448704.1
    XP_038965314.1
    XP_063143337.1
    XP_063143338.1
    XP_063143339.1
    XP_063143340.1
    XP_063143341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429742.1 → NP_001416671.1  voltage-gated potassium channel subunit beta-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NM_001429743.1 → NP_001416672.1  voltage-gated potassium channel subunit beta-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NM_001429744.1 → NP_001416673.1  voltage-gated potassium channel subunit beta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8L2Q7L3

    4. NM_001429745.1 → NP_001416674.1  voltage-gated potassium channel subunit beta-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    5. NM_001429746.1 → NP_001416675.1  voltage-gated potassium channel subunit beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P62483
      UniProtKB/TrEMBL
      A6IUI6

    6. NM_001429747.1 → NP_001416676.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6GCY0

    7. NM_001429748.1 → NP_001416677.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6GCY0

    8. NM_017304.3 → NP_059000.1  voltage-gated potassium channel subunit beta-2 isoform 5

      See identical proteins and their annotated locations for NP_059000.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P62483
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A6IUI6
      Related
      ENSRNOP00000085478.2, ENSRNOT00000101700.2
      Conserved Domains (1) summary
      cd19141
      Location:38 → 347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168182228..168270760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593214.3 → XP_017448703.1  voltage-gated potassium channel subunit beta-2 isoform X1

      Related
      ENSRNOP00000015840.3, ENSRNOT00000015840.5
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    2. XM_039109386.2 → XP_038965314.1  voltage-gated potassium channel subunit beta-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVX6
      Conserved Domains (1) summary
      cl00470
      Location:1 → 296
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    3. XM_063287270.1 → XP_063143340.1  voltage-gated potassium channel subunit beta-2 isoform X5

      Related
      ENSRNOP00000082892.2, ENSRNOT00000111948.2

    4. XM_063287268.1 → XP_063143338.1  voltage-gated potassium channel subunit beta-2 isoform X3

      Related
      ENSRNOP00000081886.1, ENSRNOT00000113173.2

    5. XM_063287269.1 → XP_063143339.1  voltage-gated potassium channel subunit beta-2 isoform X4

    6. XM_063287267.1 → XP_063143337.1  voltage-gated potassium channel subunit beta-2 isoform X2

    7. XM_017593215.3 → XP_017448704.1  voltage-gated potassium channel subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8L2Q7L3
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    8. XM_063287271.1 → XP_063143341.1  voltage-gated potassium channel subunit beta-2 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62483.1 GenPept UniProtKB/Swiss-Prot:P62483

    Gene LinkOut

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