Kcna3 potassium voltage-gated channel subfamily A member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcna3provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A member 3provided by RGD
Primary source: RGD:2951
See related: EnsemblRapid:ENSRNOG00000062002 AllianceGenome:RGD:2951
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables delayed rectifier potassium channel activity and outward rectifier potassium channel activity. Involved in corpus callosum development; optic nerve development; and potassium ion transmembrane transport. Located in membrane raft and plasma membrane. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (197320324..197322277)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (194632106..194634059)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (209766767..209768344)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome.
Title: Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome.
Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex.
Title: Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex.
Interactions of fibroblast-like synoviocytes in collagen-induced arthritis are regulated by Kv1.3 and KCa1.1
Title: KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.
The high stability and bioavailability, low normal-tissue uptake of [(64)Cu]Cu-NOTA-HsTX1[R14A], and accumulation in regions of up-regulated Kv channels both in vitro and in vivo demonstrate that HsTX1[R14A] represents a valuable lead for conditions treatable by blockade of the voltage-gated potassium channel Kv1.3.
Title: Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.
T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.
Title: Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.
PKC activation triggers down-regulation of Kv1.3 by inducing a clathrin-mediated endocytic event that targets the channel to lysosomal-degradative compartments.
Title: Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation.
Kv1.3 may be a therapeutic target of interest for multiple sclerosis and add astrocytes to the list of cells whose activation would be suppressed by inhibiting Kv1.3 in inflammatory conditions
Title: Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis.
Kv1.3 is involved in methamphetamine-mediated microglial damage
Title: Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3.
Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life
Title: Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
Kv1.3 appears to be distributed to the cis-Golgi membrane of rat astrocytes in a similar way as a Golgi resident protein.
Title: The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables outward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 3

Names: KV3; RCK3; RGK5; potassium channel, voltage gated shaker related subfamily A, member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; voltage-gated potassium channel subunit Kv1.3; voltage-gated potassium channel subunit Kv3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019270.4 → NP_062143.3 potassium voltage-gated channel subfamily A member 3

See identical proteins and their annotated locations for NP_062143.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P15384

UniProtKB/TrEMBL

A6HUR8, A6HUR9

Related

ENSRNOP00000075761.1, ENSRNOT00000092240.3

Conserved Domains (4) summary

smart00225
Location:56 → 150

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:243 → 440

Ion_trans; Ion transport protein

pfam02214
Location:56 → 147

BTB_2; BTB/POZ domain

pfam07885
Location:354 → 431

Ion_trans_2; Ion channel