Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srmsprovided by RGD
Official Full Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesprovided by RGD
Primary source: RGD:1306602
See related: EnsemblRapid:ENSRNOG00000013003 AllianceGenome:RGD:1306602
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including innate immune response; peptidyl-tyrosine autophosphorylation; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 12.3), Spleen (RPKM 10.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188696070..188702474, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (168318511..168324915, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176709742..176716146, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase Srms

NP_001011961.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011961.1 → NP_001011961.1 tyrosine-protein kinase Srms

See identical proteins and their annotated locations for NP_001011961.1

Status: PROVISIONAL

Source sequence(s)

BC090006

UniProtKB/TrEMBL

F6Y6E1, Q5FVG7

Related

ENSRNOP00000017668.5, ENSRNOT00000017668.7

Conserved Domains (4) summary

cd05148
Location:238 → 498

PTKc_Srm_Brk; Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk)

pfam07714
Location:245 → 495

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:134 → 212

SH2; Src homology 2 (SH2) domain

cl17036
Location:70 → 124

SH3; Src Homology 3 domain superfamily