Amhr2 anti-Mullerian hormone receptor type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amhr2provided by RGD
Official Full Name: anti-Mullerian hormone receptor type 2provided by RGD
Primary source: RGD:70964
See related: EnsemblRapid:ENSRNOG00000014850 AllianceGenome:RGD:70964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C14; MRII; MISRII
Summary: Enables transforming growth factor beta receptor activity, type II. Involved in female gonad development and male gonad development. Acts upstream of or within transforming growth factor beta receptor signaling pathway. Located in plasma membrane. Human ortholog(s) of this gene implicated in persistent Mullerian duct syndrome. Orthologous to human AMHR2 (anti-Mullerian hormone receptor type 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 106.1), Heart (RPKM 38.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135454517..135470183)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133579152..133588874)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144052202..144060678)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

physiological function(s) of type 2 anti-Mullerian hormone receptor
Title: The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.
Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MISRI receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression.
Title: Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression.
examined the presence of AMH receptor type II (AMHR-II) in fetal Leydig cells (FLC) and cells in the adult Leydig cells lineage in the postnatal testis; presence of AMHR-II in postnatal FLC suggests a possible role by AMH on FLC
Title: Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139894 (e-PCR)
- UniSTS:221978

RH139391 (e-PCR)
- UniSTS:221477

Amhr2 (e-PCR), detects polymorphism
- UniSTS:525956

Amhr2 (e-PCR), detects polymorphism
- UniSTS:496635

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables anti-Mullerian hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables anti-Mullerian hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anti-Mullerian hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in anti-Mullerian hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in female gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sex differentiation	ISO Inferred from Sequence Orthology more info
involved_in sex differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anti-Muellerian hormone type-2 receptor

Names: AMH type II receptor; MIS type II receptor; anti-Muellerian hormone type II receptor; anti-Mullerian hormone receptor type 11 SV1; anti-Mullerian hormone receptor, type II; anti-Mullerian hormone type 2 receptor

NP_112260.1

EC 2.7.11.30

XP_038934520.1

EC 2.7.11.30

XP_038934521.1

EC 2.7.11.30

XP_038934523.1

EC 2.7.11.30

XP_038934524.1

EC 2.7.11.30

XP_063119188.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030998.2 → NP_112260.1 anti-Muellerian hormone type-2 receptor precursor

See identical proteins and their annotated locations for NP_112260.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q62893, Q63045, Q9R0A7

UniProtKB/TrEMBL

A6KCV2

Related

ENSRNOP00000020103.5, ENSRNOT00000020103.7

Conserved Domains (2) summary

pfam01064
Location:61 → 119

Activin_recp; Activin types I and II receptor domain

cl21453
Location:205 → 506

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

135454517..135470183

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078593.2 → XP_038934521.1 anti-Muellerian hormone type-2 receptor isoform X1

UniProtKB/Swiss-Prot

Q62893, Q63045, Q9R0A7

UniProtKB/TrEMBL

A6KCV2

Conserved Domains (2) summary

pfam01064
Location:61 → 119

Activin_recp; Activin types I and II receptor domain

cl21453
Location:205 → 506

PKc_like; Protein Kinases, catalytic domain
XM_063263118.1 → XP_063119188.1 anti-Muellerian hormone type-2 receptor isoform X2
XM_039078592.2 → XP_038934520.1 anti-Muellerian hormone type-2 receptor isoform X1

UniProtKB/Swiss-Prot

Q62893, Q63045, Q9R0A7

UniProtKB/TrEMBL

A6KCV2

Conserved Domains (2) summary

pfam01064
Location:61 → 119

Activin_recp; Activin types I and II receptor domain

cl21453
Location:205 → 506

PKc_like; Protein Kinases, catalytic domain
XM_039078596.2 → XP_038934524.1 anti-Muellerian hormone type-2 receptor isoform X3

UniProtKB/TrEMBL

A0A088DKH8, A6KCV3

Related

ENSRNOP00000069243.1, ENSRNOT00000091378.3

Conserved Domains (2) summary

pfam01064
Location:61 → 119

Activin_recp; Activin types I and II receptor domain

cl21453
Location:205 → 428

PKc_like; Protein Kinases, catalytic domain
XM_039078595.2 → XP_038934523.1 anti-Muellerian hormone type-2 receptor isoform X2

Conserved Domains (2) summary

pfam01064
Location:61 → 119

Activin_recp; Activin types I and II receptor domain

cl21453
Location:206 → 429

PKc_like; Protein Kinases, catalytic domain