Ahcy adenosylhomocysteinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ahcyprovided by RGD
Official Full Name: adenosylhomocysteinaseprovided by RGD
Primary source: RGD:69260
See related: EnsemblRapid:ENSRNOG00000017777 AllianceGenome:RGD:69260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables NAD binding activity; adenosylhomocysteinase activity; and identical protein binding activity. Involved in several processes, including S-adenosylhomocysteine catabolic process; chronic inflammatory response to antigenic stimulus; and circadian sleep/wake cycle. Predicted to be located in endoplasmic reticulum; melanosome; and nucleus. Predicted to be active in cytosol. Used to study hyperhomocysteinemia and pyridoxine deficiency anemia. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1058.3), Kidney (RPKM 313.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164029338..164044562, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (143569134..143584359, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (150587833..150603057, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase.
Title: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.
Catalytic mechanism of S-adenosylhomocysteine hydrolase
Title: Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
Crystal structures of DEA alone and in complex with AdoHcyase have been determined to elucidate the DEA binding scheme to AdoHcyase
Title: Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
AdoHcy-hydrolase accumulation in the nucleus of adult mammalian cells is involved in maintaining efficient transmethylation reactions in transcriptionally active cells by removing the product inhibitor AdoHcy.
Title: Expression and localization of S-adenosylhomocysteine-hydrolase in the rat kidney following carbon monoxide induced hypoxia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141077 (e-PCR)
- UniSTS:223075

Ahcy (e-PCR), detects polymorphism
- UniSTS:526032

RH125484 (e-PCR)
- UniSTS:162303

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables adenosylhomocysteinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylhomocysteinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosylhomocysteinase activity	ISO Inferred from Sequence Orthology more info
enables adenosylselenohomocysteinase activity	TAS Traceable Author Statement more info
enables adenyl nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in S-adenosylhomocysteine catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within S-adenosylhomocysteine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in chronic inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian sleep/wake cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosylhomocysteinase

Names: S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase; adoHcyase

NP_058897.1

EC 3.13.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017201.2 → NP_058897.1 adenosylhomocysteinase

See identical proteins and their annotated locations for NP_058897.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P10760

UniProtKB/TrEMBL

A0A8I5ZM95, A6KI17

Related

ENSRNOP00000024310.1, ENSRNOT00000024310.5

Conserved Domains (2) summary

PRK05476
Location:1 → 426

PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional

pfam05221
Location:6 → 431

AdoHcyase; S-adenosyl-L-homocysteine hydrolase