Taar4 trace amine-associated receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taar4provided by RGD
Official Full Name: trace amine-associated receptor 4provided by RGD
Primary source: RGD:631382
See related: AllianceGenome:RGD:631382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ta2; taR-2; taR-4
Summary: Enables trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; behavioral fear response; and chemosensory behavior. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: mouse all
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Genomic context

Location:: 1p12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (23300288..23301331, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (21481050..21482093, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (22558787..22559830, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The different functionality of rat Taar subtypes 1 and 4 mainly correlates with receptor's cell surface expression rather than with specific amino acid residues involved in ligand binding specificity.
Title: Determinants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4.

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General gene information

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Markers

Taar4 (e-PCR), detects polymorphism
- UniSTS:516838

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-phenylethylamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled amine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in behavioral fear response	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemosensory behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of chemical stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trace amine-associated receptor 4

Names: 2-phenylethylamine receptor; trace amine receptor 2; trace amine receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175583.1 → NP_783173.1 trace amine-associated receptor 4

See identical proteins and their annotated locations for NP_783173.1

Status: PROVISIONAL

Source sequence(s)

AF380188

UniProtKB/Swiss-Prot

Q923Y7

UniProtKB/TrEMBL

D8KZP7

Conserved Domains (1) summary

pfam00001
Location:50 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)