Npy1r neuropeptide Y receptor Y1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npy1rprovided by RGD
Official Full Name: neuropeptide Y receptor Y1provided by RGD
Primary source: RGD:3198
See related: EnsemblRapid:ENSRNOG00000014149 AllianceGenome:RGD:3198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NPY-1
Summary: Predicted to enable neuropeptide binding activity; pancreatic polypeptide receptor activity; and peptide YY receptor activity. Involved in several processes, including positive regulation of cholesterol biosynthetic process; regulation of presynaptic cytosolic calcium ion concentration; and regulation of secretion by cell. Located in axon and synaptic vesicle. Is active in glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Used to study anxiety disorder; childhood absence epilepsy; depressive disorder; and hypertension. Biomarker of obesity and visual epilepsy. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 32.2), Adrenal (RPKM 20.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (27804416..27814070, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (23037788..23047330, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (24779480..24789131, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder.
Title: Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder.
Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
Title: Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn.
Title: Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn.
Orexin-A from hypothalamic lateral area neurons act on the paraventricular nucleus to enhance gastric motility and gastric acid secretion, with Y1 receptor signaling playing a critical role.
Title: Orexin-A signaling in the paraventricular nucleus promote gastric acid secretion and gastric motility through the activation neuropeptide Y Y(1) receptors and modulated by the hypothalamic lateral area.
(1) NPS efficiently prevents development of and reverses the posttraumatic stress symptomatology caused by exposure to stress; (2) the mechanisms of action involve both the NPS receptor and NPY-Y1R; and (3) NPS may affect the NPY-Y1R, indicating a possible cross talk between the NPYergic system and NPS. Treatment with NPS may be a novel approach for the treatment of the deleterious consequences of stress exposure.
Title: Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor.
The levels of NPY and NPY1R in MSCs undergoing osteoblastic differentiation were upregulated after MLT administration. results show that MLT promotes osteoblastic differentiation of MSCs and fracture healing by NPY/NPY1R signaling.
Title: Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling.
NPY and Y1 were expressed by pulmonary intravascular and intraalveolar leukocytes. Y1 was up-regulated by pulmonary intravascular and intraalveolar leukocytes during allograft rejection while Y2 could not be detected.
Title: Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts.
Results indicate that Galanin receptor 2/Neuropeptide Y Y1 receptor (GALR2/NPYY1R) interactions can provide a novel integrative mechanism in dentate gyrus in depression-related behavior and may give the basis for the development of drugs targeting GALR2/NPYY1R heteroreceptor complexes in the dentate gyrus of the hippocampus for the treatment of depression.
Title: Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects.
NPY1 receptors participate in the regulation of myocardial contractility in rats.
Title: NPY(1) Receptors Participate in the Regulation of Myocardial Contractility in Rats.
that protective properties of enriched environment on fear extinction can be regulated, at least in part, by activation of NPY-signaling through NPY-Y1 receptor within hippocampus
Title: Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation.

Submit: New GeneRIF Correction See all GeneRIFs (59)

General gene information

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Markers

UniSTS:256984 (e-PCR)
- UniSTS:256984

Npy1r (e-PCR), detects polymorphism
- UniSTS:256984

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables pancreatic polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide YY receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide YY receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling via neuropeptide	EXP Inferred from Experiment more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuropeptide Y receptor type 1

Names: FC5; NPY1-R; Neuropepetide Y1 Receptor; neuropeptide Y1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113357.1 → NP_001106828.1 neuropeptide Y receptor type 1

See identical proteins and their annotated locations for NP_001106828.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P21555

UniProtKB/TrEMBL

A6KFL5, G3V7T1

Related

ENSRNOP00000018952.4, ENSRNOT00000018952.8

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

27804416..27814070 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253025.5 → XP_006253087.1 neuropeptide Y receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_006253087.1

UniProtKB/Swiss-Prot

P21555

UniProtKB/TrEMBL

A6KFL5, G3V7T1

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006253024.5 → XP_006253086.1 neuropeptide Y receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_006253086.1

UniProtKB/Swiss-Prot

P21555

UniProtKB/TrEMBL

A6KFL5, G3V7T1

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063275269.1 → XP_063131339.1 neuropeptide Y receptor type 1 isoform X2

UniProtKB/TrEMBL

Q5FVH5

Related

ENSRNOP00000068980.1, ENSRNOT00000079412.3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013032.1: Suppressed sequence

Description

NM_001013032.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.