Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gga2provided by RGD
Full Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by RGD
Primary source: RGD:1304800
See related: EnsemblRapid:ENSRNOG00000018599 AllianceGenome:RGD:1304800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and protein localization to cell surface. Predicted to be located in Golgi apparatus and clathrin-coated vesicle. Predicted to be active in trans-Golgi network. Orthologous to human GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 433.6), Kidney (RPKM 235.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (185983302..186016582, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (176552046..176585332, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (191951578..191984858, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the expression of the GGA2 increased substantially between the 15th and 30th day after birth in all areas studied, excepting the cerebellum and cortex.
Title: Expression of coat proteins changes during postnatal development in selected areas of the rat brain.

Submit: New GeneRIF Correction

General gene information

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Markers

AU026011 (e-PCR)
- UniSTS:114700

AU025707 (e-PCR)
- UniSTS:114999

D1Rat437 (e-PCR)
- UniSTS:227220

D1Smu7 (e-PCR)
- UniSTS:517788

D1Smu8 (e-PCR)
- UniSTS:517845

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-binding protein GGA2

Names: ADP-ribosylation factor-binding protein GGA2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100519.1 → NP_001093989.1 ADP-ribosylation factor-binding protein GGA2

See identical proteins and their annotated locations for NP_001093989.1

Status: VALIDATED

Source sequence(s)

BC098781, CO558907, FM060021

UniProtKB/TrEMBL

A0A0G2JYM3, A6I8V4, G3V8F7

Related

ENSRNOP00000025309.4, ENSRNOT00000025309.7

Conserved Domains (4) summary

smart00809
Location:482 → 596

Alpha_adaptinC2; Adaptin C-terminal domain

cd03567
Location:29 → 166

VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...

cl03906
Location:229 → 317

GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins

cl21478
Location:186 → 242

ATP-synt_B; ATP synthase B/B' CF(0)