Rnaset2 ribonuclease T2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnaset2provided by RGD
Official Full Name: ribonuclease T2provided by RGD
Primary source: RGD:1309918
See related: EnsemblRapid:ENSRNOG00000013190 AllianceGenome:RGD:1309918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA endonuclease activity. Predicted to be involved in RNA catabolic process. Predicted to be located in endoplasmic reticulum lumen; extracellular space; and lysosome. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 521.0), Kidney (RPKM 490.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (55133532..55150701)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (52576344..52603151)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (53174879..53192048)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNaseT2 knockout rats exhibited memory deficits.
Title: RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables ribonuclease T2 activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribonuclease T2

NP_001099680.1

EC 4.6.1.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.