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    Stxbp5l syntaxin binding protein 5L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stxbp5lprovided by RGD
    Official Full Name
    syntaxin binding protein 5Lprovided by RGD
    Primary source
    RGD:1311561
    See related
    EnsemblRapid:ENSRNOG00000002496 AllianceGenome:RGD:1311561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within glucose homeostasis; negative regulation of insulin secretion; and regulation of exocytosis. Predicted to be part of SNARE complex. Predicted to be active in neuromuscular junction; neuronal dense core vesicle; and plasma membrane. Orthologous to human STXBP5L (syntaxin binding protein 5L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 248.3), Testes (RPKM 63.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stxbp5l in Genome Data Viewer
    Location:
    11q21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76838839..77167852)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63334667..63654270)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66246624..66566331)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene homogentisate 1, 2-dioxygenase Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene general transcription factor IIE subunit 1 Neighboring gene U2 spliceosomal RNA Neighboring gene ring finger protein 138, pseudogene 4 Neighboring gene DNA polymerase theta Neighboring gene G protein subunit gamma 10, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. Bhatnagar S, et al. PLoS Genet, 2011 Oct. PMID 21998599, Free PMC Article
    2. Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains. Geerts CJ, et al. PLoS One, 2017. PMID 28746398, Free PMC Article
    3. Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates. Geerts CJ, et al. Brain Struct Funct, 2015 Jul. PMID 24744148
    4. Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. Williams AL, et al. J Biol Chem, 2011 Apr 22. PMID 21330375, Free PMC Article
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-binding protein 5-like
    Names
    syntaxin binding protein 5-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271250.2 → NP_001258179.1  syntaxin-binding protein 5-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IR95
      Related
      ENSRNOP00000044583.7, ENSRNOT00000041715.8
      Conserved Domains (5) summary
      COG2319
      Location:108 → 503
      WD40; WD40 repeat [General function prediction only]
      cd15893
      Location:1118 → 1178
      R-SNARE_STXBP5; SNARE domain of STXBP5
      pfam08366
      Location:288 → 395
      LLGL; LLGL2
      sd00039
      Location:73 → 106
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:73 → 280
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001429132.1 → NP_001416061.1  syntaxin-binding protein 5-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IR95

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      76838839..77167852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270382.1 → XP_063126452.1  syntaxin-binding protein 5-like isoform X1

    2. XM_063270385.1 → XP_063126455.1  syntaxin-binding protein 5-like isoform X3

      UniProtKB/TrEMBL
      A6IR95
      Related
      ENSRNOP00000101329.1, ENSRNOT00000139253.1

    3. XM_063270384.1 → XP_063126454.1  syntaxin-binding protein 5-like isoform X2

      Related
      ENSRNOP00000099176.1, ENSRNOT00000153449.1

    4. XM_063270386.1 → XP_063126456.1  syntaxin-binding protein 5-like isoform X4

      UniProtKB/TrEMBL
      A6IR95

    5. XM_063270383.1 → XP_063126453.1  syntaxin-binding protein 5-like isoform X1

      UniProtKB/TrEMBL
      A6IR95

    6. XM_063270387.1 → XP_063126457.1  syntaxin-binding protein 5-like isoform X5

      UniProtKB/TrEMBL
      A6IR95, D3ZU84

    7. XM_063270388.1 → XP_063126458.1  syntaxin-binding protein 5-like isoform X6

    8. XM_063270389.1 → XP_063126459.1  syntaxin-binding protein 5-like isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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