Zfp689 zinc finger protein 689 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp689provided by RGD
Official Full Name: zinc finger protein 689provided by RGD
Primary source: RGD:628696
See related: EnsemblRapid:ENSRNOG00000066277 AllianceGenome:RGD:628696
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hit39; Znf689
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human ZNF689 (zinc finger protein 689). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 30.1), Thymus (RPKM 26.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191496370..191507277, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182065885..182074343, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198894000..198900364, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137393 (e-PCR)
- UniSTS:219481

BE114196 (e-PCR)
- UniSTS:247438

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 689

Names: transcription factor HIT-39; zinc finger protein HIT-39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173330.2 → NP_775452.1 zinc finger protein 689

See identical proteins and their annotated locations for NP_775452.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q99PJ7

UniProtKB/TrEMBL

B5DEF2

Related

ENSRNOP00000103030.1, ENSRNOT00000167283.1

Conserved Domains (5) summary

smart00349
Location:29 → 88

KRAB; krueppel associated box

COG5048
Location:159 → 466

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:263 → 283

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:29 → 68

KRAB; KRAB box

pfam13465
Location:303 → 328

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

191496370..191507277 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102767.2 → XP_038958695.1 zinc finger protein 689 isoform X1

UniProtKB/TrEMBL

A0A8I6A643

Related

ENSRNOP00000024969.5, ENSRNOT00000024969.9

Conserved Domains (3) summary

smart00349
Location:29 → 97

KRAB; krueppel associated box

COG5048
Location:121 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:225 → 245

ZF_C2H2; C2H2 Zn finger [structural motif]