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    PRELP proline and arginine rich end leucine rich repeat protein [ Bos taurus (domestic cattle) ]

    Gene ID: 282000, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PRELPprovided by VGNC
    Official Full Name
    proline and arginine rich end leucine rich repeat proteinprovided by VGNC
    Primary source
    VGNC:VGNC:33309
    See related
    BGD:BT26498; Ensembl:ENSBTAG00000017834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PRELP in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (1238715..1252743)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107133214 Neighboring gene BTG anti-proliferation factor 2 Neighboring gene fibromodulin Neighboring gene uncharacterized LOC112441938 Neighboring gene opticin Neighboring gene ATPase plasma membrane Ca2+ transporting 4 Neighboring gene uncharacterized LOC132342430

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The amino-terminal part of PRELP binds to heparin and heparan sulfate. Bengtsson E, et al. J Biol Chem, 2000 Dec 29. PMID 11007795
    2. The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. Bengtsson E, et al. J Biol Chem, 2002 Apr 26. PMID 11847210
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolargin
    Names
    proline arginine-rich end leucine-rich repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174434.3 → NP_776859.1  prolargin precursor

      See identical proteins and their annotated locations for NP_776859.1

      Status: PROVISIONAL

      Source sequence(s)
      AF163568
      UniProtKB/Swiss-Prot
      Q9GKN8
      Conserved Domains (4) summary
      smart00013
      Location:71 → 106
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:143 → 361
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:103 → 126
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:101 → 161
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      1238715..1252743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216651.5 → XP_005216708.2  prolargin isoform X1

      UniProtKB/TrEMBL
      A6QQQ3, F1MX63
      Related
      ENSBTAP00000023709.6, ENSBTAT00000023709.7
      Conserved Domains (4) summary
      smart00013
      Location:71 → 106
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:103 → 126
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:101 → 161
      LRR_8; Leucine rich repeat
      cl26018
      Location:132 → 352
      NEL; C-terminal novel E3 ligase, LRR-interacting
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GKN8.1 GenPept UniProtKB/Swiss-Prot:Q9GKN8

    Gene LinkOut

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