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    CRYL1 crystallin lambda 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281725, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CRYL1provided by VGNC
    Official Full Name
    crystallin lambda 1provided by VGNC
    Primary source
    VGNC:VGNC:27744
    See related
    BGD:BT27378; Ensembl:ENSBTAG00000011726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CRYL1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (35928798..35985471)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346770 Neighboring gene interleukin 17D Neighboring gene intraflagellar transport 88 Neighboring gene uncharacterized LOC104973587 Neighboring gene snRNA-activating protein complex subunit 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. Chen J, et al. Gene, 2003 Jan 2. PMID 12527201
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-gulonate 3-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lambda-crystallin homolog
    Names
    L-gulonate 3-dehydrogenase
    gul3DH
    NP_776718.1
    XP_024855548.1
    XP_059747937.1
    XP_059747938.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174293.2 → NP_776718.1  lambda-crystallin homolog

      See identical proteins and their annotated locations for NP_776718.1

      Status: PROVISIONAL

      Source sequence(s)
      AF480862
      UniProtKB/Swiss-Prot
      Q8SPX7
      UniProtKB/TrEMBL
      A5D7R4
      Related
      ENSBTAP00000015575.5, ENSBTAT00000015575.7
      Conserved Domains (3) summary
      PRK06129
      Location:8 → 317
      PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
      pfam00725
      Location:195 → 283
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:12 → 189
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35928798..35985471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891954.1 → XP_059747937.1  lambda-crystallin homolog isoform X1

    2. XM_024999780.2 → XP_024855548.1  lambda-crystallin homolog isoform X2

      UniProtKB/TrEMBL
      A0AAA9U1X8, A5D7R4
      Related
      ENSBTAP00000103322.1, ENSBTAT00000114544.1
      Conserved Domains (1) summary
      cl27647
      Location:15 → 314
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

    3. XM_059891955.1 → XP_059747938.1  lambda-crystallin homolog isoform X3

      UniProtKB/TrEMBL
      A5D7R4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SPX7.3 GenPept UniProtKB/Swiss-Prot:Q8SPX7

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