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    GNB1 G protein subunit beta 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281201, updated on 4-Oct-2024

    Summary

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    Official Symbol
    GNB1provided by VGNC
    Official Full Name
    G protein subunit beta 1provided by VGNC
    Primary source
    VGNC:VGNC:29457
    See related
    BGD:BT11474; Ensembl:ENSBTAG00000000215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HG2A
    Orthologs
    human mouse all
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    Genomic context

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    See GNB1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (50856295..50933401)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene calmodulin like 6 Neighboring gene U6 spliceosomal RNA Neighboring gene NAD kinase Neighboring gene uncharacterized LOC104974460 Neighboring gene solute carrier family 35 member E2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure of the beta-subunit of bovine transducin deduced from the cDNA sequence. Sugimoto K, et al. FEBS Lett, 1985 Oct 28. PMID 2414128
    2. Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Fong HK, et al. Proc Natl Acad Sci U S A, 1986 Apr. PMID 3083416, Free PMC Article
    3. Proteomic analysis of transducin beta-subunit structural heterogeneity. Clack JW, et al. Electrophoresis, 2003 Oct. PMID 14595696
    4. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Lodowski DT, et al. Science, 2003 May 23. PMID 12764189
    5. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Sondek J, et al. Nature, 1996 Jan 25. PMID 8552196

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that a hetero-multimer complex forms between light-activated rhodopsin and light-activated heterotrimeric transducin (T-alpha-1, Gnb1, Gngt1); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.
      Title: Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex.
    2. The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain.
      Title: Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gβ1γ2 Complex.
    3. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits
      Title: Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
    4. conclude that GNB1 constitutes over 99% of the GNbeta expressed in bovine rod outer segments and displays structural heterogeneity that is due to post-translational modification, some of which is due to phosphorylation of GNB1.
      Title: Proteomic analysis of transducin beta-subunit structural heterogeneity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129044

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Names
    guanine nucleotide-binding protein, beta-1 subunit
    heterotrimeric guanine nucleotide-binding protein 2A
    transducin beta chain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175777.3 → NP_786971.2  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_786971.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105260
      UniProtKB/Swiss-Prot
      P62871, Q3MHF1
      UniProtKB/TrEMBL
      A7E3V7
      Related
      ENSBTAP00000042481.1, ENSBTAT00000045065.3
      Conserved Domains (2) summary
      cd00200
      Location:48 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50856295..50933401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005217017.3 → XP_005217074.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_005217074.1

      UniProtKB/Swiss-Prot
      P62871, Q3MHF1
      UniProtKB/TrEMBL
      A7E3V7
      Conserved Domains (2) summary
      cd00200
      Location:48 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62871.3 GenPept UniProtKB/Swiss-Prot:P62871

    Gene LinkOut

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