Tbl2 transducin (beta)-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbl2provided by MGI
Official Full Name: transducin (beta)-like 2provided by MGI
Primary source: MGI:MGI:1351652
See related: Ensembl:ENSMUSG00000005374 AllianceGenome:MGI:1351652
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WS-bTRP
Summary: Predicted to enable phosphoprotein binding activity; protein kinase binding activity; and translation initiation factor binding activity. Predicted to be involved in cellular response to glucose starvation; cellular response to hypoxia; and endoplasmic reticulum unfolded protein response. Predicted to be active in endoplasmic reticulum. Orthologous to human TBL2 (transducin beta like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 13.5), limb E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.02 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (135178288..135192727)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (135149429..135163873)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW493804 (e-PCR)
- UniSTS:207895

D5Mit283 (e-PCR), detects polymorphism
- UniSTS:130421

Tbl2 (e-PCR), detects polymorphism
- UniSTS:230799

C76179 (e-PCR)
- UniSTS:159456

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transducin beta-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363307.1 → NP_001350236.1 transducin beta-like protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC024607

Conserved Domains (2) summary

sd00039
Location:45 → 89

7WD40; WD40 repeat [structural motif]

cl29593
Location:2 → 210

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_013763.3 → NP_038791.2 transducin beta-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_038791.2

Status: VALIDATED

Source sequence(s)

AC024607, AK047090, AK132366, BC048185, BE947541

Consensus CDS

CCDS19735.1

UniProtKB/Swiss-Prot

Q8CFY0, Q9R099

UniProtKB/TrEMBL

Q9CY49

Related

ENSMUSP00000115011.2, ENSMUST00000153183.8

Conserved Domains (3) summary

COG2319
Location:82 → 394

WD40; WD40 repeat [General function prediction only]

sd00039
Location:89 → 132

7WD40; WD40 repeat [structural motif]

cl02567
Location:78 → 394

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

135178288..135192727

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504432.5 → XP_006504495.1 transducin beta-like protein 2 isoform X1

UniProtKB/TrEMBL

Q9CY49

Conserved Domains (2) summary

sd00039
Location:60 → 103

7WD40; WD40 repeat [structural motif]

cl29593
Location:49 → 365

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030254546.2 → XP_030110406.1 transducin beta-like protein 2 isoform X2

Conserved Domains (2) summary

sd00039
Location:45 → 89

7WD40; WD40 repeat [structural motif]

cl29593
Location:2 → 210

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...