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    TMEM98 transmembrane protein 98 [ Homo sapiens (human) ]

    Gene ID: 26022, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM98provided by HGNC
    Official Full Name
    transmembrane protein 98provided by HGNC
    Primary source
    HGNC:HGNC:24529
    See related
    Ensembl:ENSG00000006042 MIM:615949; AllianceGenome:HGNC:24529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TADA1
    Summary
    This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 69.4), endometrium (RPKM 44.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM98 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32928153..32944315)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33874221..33890387)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (31255171..31271333)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin ID Neighboring gene Sharpr-MPRA regulatory region 12414 Neighboring gene uncharacterized LOC124903981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12039 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:31203674-31203861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:31213662-31214258 Neighboring gene CRISPRi-validated MYO1D non-hub enhancer 1 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1747 Neighboring gene Sharpr-MPRA regulatory region 12135 Neighboring gene CRISPRi-validated MYO1D hub enhancer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:31244864-31245495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31262798-31263448 Neighboring gene Sharpr-MPRA regulatory region 812 Neighboring gene MYO1D divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr17:31329363-31329898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31341295-31341796 Neighboring gene H2B.N variant histone 1 Neighboring gene uncharacterized LOC105371737 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:31439262-31440461 Neighboring gene sperm acrosome associated 3 Neighboring gene acid sensing ion channel subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564K1964

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 1 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034264.2 RefSeqGene

      Range
      5002..21164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033504.2NP_001028676.1  transmembrane protein 98

      See identical proteins and their annotated locations for NP_001028676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC084809, AY358573
      Consensus CDS
      CCDS11274.1
      UniProtKB/Swiss-Prot
      E1P631, Q9UFK2, Q9Y2Y6
      UniProtKB/TrEMBL
      B2R8Z5
      Related
      ENSP00000378138.3, ENST00000394642.7
      Conserved Domains (1) summary
      pfam13324
      Location:48152
      GCIP; Grap2 and cyclin-D-interacting
    2. NM_001301746.2NP_001288675.1  transmembrane protein 98

      See identical proteins and their annotated locations for NP_001288675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC084809, AY358573, BQ228781
      Consensus CDS
      CCDS11274.1
      UniProtKB/Swiss-Prot
      E1P631, Q9UFK2, Q9Y2Y6
      UniProtKB/TrEMBL
      B2R8Z5
      Related
      ENSP00000406394.1, ENST00000439138.5
      Conserved Domains (1) summary
      pfam13324
      Location:48152
      GCIP; Grap2 and cyclin-D-interacting
    3. NM_015544.3NP_056359.2  transmembrane protein 98

      See identical proteins and their annotated locations for NP_056359.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents a predominant transcript. This variant and variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC084809, AY358573
      Consensus CDS
      CCDS11274.1
      UniProtKB/Swiss-Prot
      E1P631, Q9UFK2, Q9Y2Y6
      UniProtKB/TrEMBL
      B2R8Z5
      Related
      ENSP00000463245.1, ENST00000579849.6
      Conserved Domains (1) summary
      pfam13324
      Location:48152
      GCIP; Grap2 and cyclin-D-interacting

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      32928153..32944315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      33874221..33890387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)