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    rhp23 UV excision repair protein rhp23 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540481, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rhp23
    Official Full Name
    UV excision repair protein rhp23
    Primary source
    PomBase:SPBC2D10.12
    Locus tag
    SPOM_SPBC2D10.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rhp23 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003423.3 (2986929..2988489)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleosome assembly protein Nap2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene telomerase regulator Est1 Neighboring gene myosin type V

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in vitro and in vivo. Medina B, et al. J Biol Chem, 2012 Dec 7. PMID 23038266, Free PMC Article
    2. Identification and characterization of the rhp23(+) DNA repair gene in Schizosaccharomyces pombe. Lombaerts M, et al. Biochem Biophys Res Commun, 2000 Feb 5. PMID 10652237
    3. Characterisation of the nascent polypeptide-associated complex in fission yeast. Andersen KM, et al. Mol Biol Rep, 2007 Dec. PMID 17211518
    4. Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage. Fukumoto Y, et al. DNA Repair (Amst), 2002 Oct 1. PMID 12531030
    5. Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination. Elder RT, et al. Nucleic Acids Res, 2002 Jan 15. PMID 11788722, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. internal Rhp23 UBA1 domain provides sufficient Ub recognition for the protein to function without UBA2.
      Title: The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in vitro and in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UV excision repair protein rhp23

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2986929..2988489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022151.3 → NP_596231.1  UV excision repair protein rhp23 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596231.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74803
      Conserved Domains (5) summary
      cd01805
      Location:1 → 76
      RAD23_N; Ubiquitin-like domain of RAD23
      cd14378
      Location:141 → 187
      UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
      cd14381
      Location:321 → 360
      UBA2_Rhp23p_like; UBA2 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its fungal homologs
      TIGR00601
      Location:1 → 363
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:247 → 302
      XPC-binding; XPC-binding domain
    Nucleotide Protein
    Heading Accession and Version

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