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    Cdkn2a cyclin-dependent kinase inhibitor 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25163, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cdkn2aprovided by RGD
    Official Full Name
    cyclin-dependent kinase inhibitor 2Aprovided by RGD
    Primary source
    RGD:2323
    See related
    EnsemblRapid:ENSRNOG00000059837 AllianceGenome:RGD:2323
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arf; p16; MTS1; INK4A; p19ARF; p16Cdkn2a
    Summary
    Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Predicted to be located in mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Predicted to be part of protein-containing complex. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 6.0), Thymus (RPKM 4.6) and 7 other tissues See more
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    Genomic context

    See Cdkn2a in Genome Data Viewer
    Location:
    5q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (109100763..109114448, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (103984949..103992143, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (107823323..107832405, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene methylthioadenosine phosphorylase Neighboring gene RNA N6-adenosine-methyltransferase METTL16-like Neighboring gene GSK3B interacting protein, pseudogene 1 Neighboring gene uncharacterized LOC134479006 Neighboring gene cyclin-dependent kinase inhibitor 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin ligase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of apoptotic process involved in mammary gland involution ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in nuclear body organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oncogene-induced cell senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process involved in mammary gland involution ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within rRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replicative senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to caloric restriction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in somatic stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in granular component ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in senescence-associated heterochromatin focus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase inhibitor 2A
    Names
    CDK4I
    Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4)
    alternative reading frame
    cell cycle inhibitor
    cell cycle regulator
    cyclin-dependent kinase 4 inhibitor A
    cyclin-dependent kinase inhibitor 2a p16Ink4a
    cyclin-dependent kinase inhibitor 2a p19Arf
    p16-INK4
    p16-INK4a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031550.2NP_113738.1  cyclin-dependent kinase inhibitor 2A

      See identical proteins and their annotated locations for NP_113738.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9R0Z3
      UniProtKB/TrEMBL
      A0A0G2K4G8, A6JRF2
      Related
      ENSRNOP00000087870.1, ENSRNOT00000103638.2
      Conserved Domains (2) summary
      COG0666
      Location:15123
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:3666
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      109100763..109114448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287166.1XP_063143236.1  cyclin-dependent kinase inhibitor 2A isoform X1