U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    GstT2 Glutathione S transferase T2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246386, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GstT2provided by FlyBase
    Official Full Name
    Glutathione S transferase T2provided by FlyBase
    Primary source
    FLYBASE:FBgn0050005
    Locus tag
    Dmel_CG30005
    See related
    AllianceGenome:FB:FBgn0050005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12930; CG12930A; CG30005; Dmel\CG30005; DmGSTT2; gstt2; GSTT2
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GstT2 in Genome Data Viewer
    Location:
    45F6-45F6; 2-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9607292..9608350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5494797..5495855)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44285 Neighboring gene antisense RNA:CR44069 Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase T1 Neighboring gene Matrix metalloproteinase 2 Neighboring gene mir-307b stem loop Neighboring gene mir-307a stem loop

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article
    2. Structural Analysis of the Drosophila melanogaster GSTome. Petiot N, et al. Biomolecules, 2024 Jun 26. PMID 39062473, Free PMC Article
    3. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
    4. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Saisawang C, et al. Biochem J, 2012 Feb 15. PMID 22082028
    5. Molecular evolution of glutathione S-transferases in the genus Drosophila. Low WY, et al. Genetics, 2007 Nov. PMID 18039872, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutathione S transferase T2
    Names
    CG30005-PA
    GstT2-PA
    NP_724816.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9607292..9608350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165690.4 → NP_724816.3  glutathione S transferase T2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724816.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7X7, H0RNE2
      Conserved Domains (3) summary
      COG0625
      Location:7 → 202
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:5 → 80
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
      cl02776
      Location:93 → 218
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7X7 A1Z7X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous