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    Tor1aip1 torsin 1A interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246314, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tor1aip1provided by RGD
    Official Full Name
    torsin 1A interacting protein 1provided by RGD
    Primary source
    RGD:628851
    See related
    EnsemblRapid:ENSRNOG00000003946 AllianceGenome:RGD:628851
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lap1b; Lap1c
    Summary
    Enables lamin binding activity. Predicted to be involved in nuclear membrane organization; positive regulation of ATP-dependent activity; and protein localization to nucleus. Predicted to act upstream of or within protein localization to nuclear envelope. Located in nuclear envelope. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Y. Orthologous to human TOR1AIP1 (torsin 1A interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 163.5), Adrenal (RPKM 160.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tor1aip1 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (70746941..70776382, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68196681..68226121, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73670649..73704668, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096287 Neighboring gene centrosomal protein 350 Neighboring gene interferon induced transmembrane protein 2, pseudogene 2 Neighboring gene torsin 1A interacting protein 2 Neighboring gene family with sequence similarity 163, member A Neighboring gene uncharacterized LOC120096289 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC93149

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lamin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in nuclear membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nuclear membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    torsin-1A-interacting protein 1
    Names
    lamina-associated polypeptide 1B
    lamina-associated polypeptide 1C
    torsin A interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145092.2NP_659560.2  torsin-1A-interacting protein 1

      See identical proteins and their annotated locations for NP_659560.2

      Status: PROVISIONAL

      Source sequence(s)
      BC086987
      UniProtKB/Swiss-Prot
      Q5PQX1, Q62741, Q62754
      UniProtKB/TrEMBL
      A0A8I6AGC6, A6ICZ9
      Related
      ENSRNOP00000005280.4, ENSRNOT00000005280.8
      Conserved Domains (1) summary
      pfam05609
      Location:162582
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      70746941..70776382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090334.2XP_038946262.1  torsin-1A-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2B4, A0A8I6AGC6
      Related
      ENSRNOP00000085745.1, ENSRNOT00000098741.2
      Conserved Domains (1) summary
      pfam05609
      Location:162547
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    2. XM_006250028.5XP_006250090.1  torsin-1A-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006250090.1

      Conserved Domains (1) summary
      pfam05609
      Location:1395
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    3. XM_006250027.5XP_006250089.1  torsin-1A-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006250089.1

      Conserved Domains (1) summary
      pfam05609
      Location:1395
      LAP1C; Lamina-associated polypeptide 1C (LAP1C)