Retsat retinol saturase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Retsatprovided by RGD
Official Full Name: retinol saturaseprovided by RGD
Primary source: RGD:628802
See related: EnsemblRapid:ENSRNOG00000014090 AllianceGenome:RGD:628802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rmt7
Summary: Predicted to enable all-trans-retinol 13,14-reductase activity. Predicted to be involved in retinol metabolic process. Predicted to be located in nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1579.4), Adrenal (RPKM 1173.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106211459..106220222)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104653306..104662069)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100465365..100474128)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol 13,14-reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol 13,14-reductase activity	IEA Inferred from Electronic Annotation more info
enables all-trans-retinol 13,14-reductase activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol 13,14-reductase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: all-trans-retinol 13,14-reductase

Names: PPAR-alpha-regulated and starvation-induced gene protein; RMT-7; all-trans-13,14-dihydroretinol saturase; hypothetical protein RMT-7; retinol saturase (all trans retinol 13,14 reductase)

NP_659552.1

EC 1.3.99.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145084.1 → NP_659552.1 all-trans-retinol 13,14-reductase precursor

See identical proteins and their annotated locations for NP_659552.1

Status: PROVISIONAL

Source sequence(s)

AF465614

UniProtKB/Swiss-Prot

Q8VHE9

UniProtKB/TrEMBL

A0A8I6A1R3, A6IAD0

Related

ENSRNOP00000084674.1, ENSRNOT00000111459.2

Conserved Domains (3) summary

COG0446
Location:25 → 103

FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

COG1233
Location:68 → 566

COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

cl21454
Location:68 → 568

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins