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    Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24470, updated on 27-Nov-2024

    Summary

    Symbol
    Hsd3b5provided by RGD
    Full Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5provided by RGD
    Primary source
    RGD:2838
    See related
    EnsemblRapid:ENSRNOG00000019417 AllianceGenome:RGD:2838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hsd1; Hsd3b; RATHSDI
    Summary
    Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity and steroid binding activity. Involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 1941.1), Liver (RPKM 392.8) and 1 other tissue See more
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    Genomic context

    See Hsd3b5 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (188697669..188717141, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (186008944..186028417, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (200615910..200633317, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100892 Neighboring gene zinc finger protein 697 Neighboring gene uncharacterized LOC134485937 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5, pseudogene 1 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in progesterone metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NADPH-dependent 3-keto-steroid reductase Hsd3b5
    Names
    3 beta-HSD III
    3 beta-hydroxysteroid dehydrogenase 5
    3 beta-hydroxysteroid dehydrogenase type 3
    3 beta-hydroxysteroid dehydrogenase type 5
    3 beta-hydroxysteroid dehydrogenase type 5-like
    3 beta-hydroxysteroid dehydrogenase type III
    3 beta-hydroxysteroid dehydrogenase type V
    3-beta-HSD V
    3-beta-hydroxy-5-ene steroid dehydrogenase
    NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
    dihydrotestosterone 3-ketoreductase
    progesterone reductase
    steroid delta-isomerase, 3 beta
    NP_036716.2
    XP_038957645.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012584.2NP_036716.2  NADPH-dependent 3-keto-steroid reductase Hsd3b5

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P27364, Q569C6
      UniProtKB/TrEMBL
      A0A0G2JSR3, A6K3D9
      Related
      ENSRNOP00000072555.1, ENSRNOT00000079754.3
      Conserved Domains (1) summary
      cl21454
      Location:5357
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      188697669..188717141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101717.2XP_038957645.1  NADPH-dependent 3-keto-steroid reductase Hsd3b5 isoform X1

      UniProtKB/Swiss-Prot
      P27364, Q569C6
      Conserved Domains (1) summary
      cl21454
      Location:5302
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins