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    Zbtb6 zinc finger and BTB domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 241322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb6provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 6provided by MGI
    Primary source
    MGI:MGI:2442998
    See related
    Ensembl:ENSMUSG00000066798 AllianceGenome:MGI:2442998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZID; Zfp482; A830092L04Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in mitochondrion. Predicted to be active in nucleoplasm. Is expressed in several structures, including bladder; intestine smooth muscle circular layer; nervous system; and retina. Orthologous to human ZBTB6 (zinc finger and BTB domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 5.5), whole brain E14.5 (RPKM 4.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb6 in Genome Data Viewer
    Location:
    2 B; 2 24.19 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37315512..37320931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37425500..37430919, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4441 Neighboring gene STARR-seq mESC enhancer starr_04312 Neighboring gene phosducin-like Neighboring gene STARR-positive B cell enhancer ABC_E7813 Neighboring gene ring finger and CCCH-type zinc finger domains 2 Neighboring gene STARR-seq mESC enhancer starr_04313 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene STARR-positive B cell enhancer ABC_E1244 Neighboring gene STARR-positive B cell enhancer ABC_E11130 Neighboring gene STARR-positive B cell enhancer ABC_E4442 Neighboring gene STARR-positive B cell enhancer ABC_E1004 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RAB GTPase activating protein 1 Neighboring gene nucleoporin 37 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
    3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Zbtb26

    Homology

    Clone Names

    • MGC41441

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 6
    Names
    zinc finger protein 482

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146253.5 → NP_666365.1  zinc finger and BTB domain-containing protein 6

      See identical proteins and their annotated locations for NP_666365.1

      Status: VALIDATED

      Source sequence(s)
      AK050827, AL953890, CF168206
      Consensus CDS
      CCDS16000.1
      UniProtKB/Swiss-Prot
      A2AWA4, Q8BLM4, Q8K088
      Related
      ENSMUSP00000056100.6, ENSMUST00000053098.6
      Conserved Domains (5) summary
      smart00225
      Location:34 → 127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325 → 347
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:23 → 123
      BTB; BTB/POZ domain
      pfam13465
      Location:339 → 363
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      37315512..37320931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K088.1 GenPept UniProtKB/Swiss-Prot:Q8K088

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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