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    Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 240332, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc6a7provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, L-proline), member 7provided by MGI
    Primary source
    MGI:MGI:2147363
    See related
    Ensembl:ENSMUSG00000052026 AllianceGenome:MGI:2147363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PROT
    Summary
    Enables L-proline transmembrane transporter activity. Acts upstream of or within proline transmembrane transport. Predicted to be located in synaptic membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; presynaptic membrane; and synaptic vesicle membrane. Is expressed in brain; early conceptus; metanephros; and secondary oocyte. Orthologous to human SLC6A7 (solute carrier family 6 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 8.4), cortex adult (RPKM 7.4) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc6a7 in Genome Data Viewer
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61128448..61147484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60995376..61014416, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II alpha Neighboring gene microRNA 7220 Neighboring gene microRNA 6982 Neighboring gene STARR-positive B cell enhancer ABC_E10994 Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351 Neighboring gene platelet derived growth factor receptor, beta polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC61029, MGC67444

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-proline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proline transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium-dependent proline transporter
    Names
    solute carrier family 6 member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418406.1NP_001405335.1  sodium-dependent proline transporter isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124431
    2. NM_201353.2NP_958741.1  sodium-dependent proline transporter isoform 1

      See identical proteins and their annotated locations for NP_958741.1

      Status: VALIDATED

      Source sequence(s)
      AC124431
      Consensus CDS
      CCDS29278.1
      UniProtKB/Swiss-Prot
      Q6PGE7, Q80UM1
      Related
      ENSMUSP00000025520.8, ENSMUST00000025520.10
      Conserved Domains (1) summary
      cl00456
      Location:37581
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61128448..61147484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250459.2XP_030106319.1  sodium-dependent proline transporter isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:1500
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006525930.4XP_006525993.1  sodium-dependent proline transporter isoform X1

      See identical proteins and their annotated locations for XP_006525993.1

      Conserved Domains (1) summary
      cl00456
      Location:84628
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_006525929.4XP_006525992.1  sodium-dependent proline transporter isoform X1

      See identical proteins and their annotated locations for XP_006525992.1

      Conserved Domains (1) summary
      cl00456
      Location:84628
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_006525931.5XP_006525994.1  sodium-dependent proline transporter isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:19563
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_006525932.3XP_006525995.1  sodium-dependent proline transporter isoform X3

      See identical proteins and their annotated locations for XP_006525995.1

      Conserved Domains (1) summary
      cl00456
      Location:1500
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    6. XM_017317902.3XP_017173391.1  sodium-dependent proline transporter isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:84410
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    7. XM_011246931.1XP_011245233.1  sodium-dependent proline transporter isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:84336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    8. XM_006525935.4XP_006525998.1  sodium-dependent proline transporter isoform X6

      Conserved Domains (1) summary
      cl00456
      Location:84333
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain