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    AU021092 expressed sequence AU021092 [ Mus musculus (house mouse) ]

    Gene ID: 239691, updated on 27-Nov-2024

    Summary

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    Official Symbol
    AU021092provided by MGI
    Official Full Name
    expressed sequence AU021092provided by MGI
    Primary source
    MGI:MGI:2146559
    See related
    Ensembl:ENSMUSG00000051669 AllianceGenome:MGI:2146559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be located in extracellular region. Predicted to be active in cytosol and membrane. Is expressed in foregut; male reproductive gland or organ; metanephros; and respiratory system. Orthologous to human C16orf89 (chromosome 16 open reading frame 89). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 52.8), ovary adult (RPKM 31.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See AU021092 in Genome Data Viewer
    Location:
    16 A1; 16 2.51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (5029677..5040170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5211814..5222308, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SEC14-like lipid binding 5 Neighboring gene N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Neighboring gene microRNA 6364 Neighboring gene STARR-positive B cell enhancer mm9_chr16:5233472-5233773 Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase Neighboring gene predicted gene 15983 Neighboring gene predicted gene, 57635

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Initial characterization of C16orf89, a novel thyroid-specific gene. Afink GB, et al. Thyroid, 2010 Jul. PMID 20578903
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UPF0764 protein C16orf89 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033220.4 → NP_001028392.2  UPF0764 protein C16orf89 homolog isoform 1 precursor

      See identical proteins and their annotated locations for NP_001028392.2

      Status: VALIDATED

      Source sequence(s)
      AC124576
      Consensus CDS
      CCDS27934.1
      UniProtKB/Swiss-Prot
      B7ZWC6, Q3UST5
      Related
      ENSMUSP00000058860.5, ENSMUST00000050160.6
      Conserved Domains (1) summary
      pfam15882
      Location:56 → 334
      DUF4735; Domain of unknown function (DUF4735)

    2. NM_001417142.1 → NP_001404071.1  UPF0764 protein C16orf89 homolog isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124576

    3. NM_001417143.1 → NP_001404072.1  UPF0764 protein C16orf89 homolog isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124576

    4. NM_001417144.1 → NP_001404073.1  UPF0764 protein C16orf89 homolog isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124576

    5. NM_001417145.1 → NP_001404074.1  UPF0764 protein C16orf89 homolog isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124576

    6. NM_001417146.1 → NP_001404075.1  UPF0764 protein C16orf89 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC124576

    RNA

    1. NR_184425.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124576

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      5029677..5040170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159915.1 → XP_036015808.1  UPF0764 protein C16orf89 homolog isoform X3

      Conserved Domains (1) summary
      pfam15882
      Location:56 → 116
      DUF4735; Domain of unknown function (DUF4735)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UST5.2 GenPept UniProtKB/Swiss-Prot:Q3UST5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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