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    Homez homeodomain leucine zipper-encoding gene [ Mus musculus (house mouse) ]

    Gene ID: 239099, updated on 9-Dec-2024

    Summary

    Official Symbol
    Homezprovided by MGI
    Official Full Name
    homeodomain leucine zipper-encoding geneprovided by MGI
    Primary source
    MGI:MGI:2678023
    See related
    Ensembl:ENSMUSG00000057156 AllianceGenome:MGI:2678023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1443
    Summary
    Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including enteric nervous system; future brain; genitourinary system; liver; and sensory organ. Orthologous to human HOMEZ (homeobox and leucine zipper encoding). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.4), ovary adult (RPKM 1.6) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Homez in Genome Data Viewer
    Location:
    14 C3; 14 27.96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55090193..55109285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54852736..54871728, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Neighboring gene ring finger protein 212B Neighboring gene STARR-seq mESC enhancer starr_36747 Neighboring gene predicted gene, 17772 Neighboring gene STARR-positive B cell enhancer ABC_E4110 Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox and leucine zipper protein Homez
    Names
    homeodomain leucine zipper-containing factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177705.2NP_001171176.1  homeobox and leucine zipper protein Homez isoform 1

      See identical proteins and their annotated locations for NP_001171176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116591
      Consensus CDS
      CCDS27102.1
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
      UniProtKB/TrEMBL
      A0A0R4J108
      Related
      ENSMUSP00000117828.2, ENSMUST00000142283.4
      Conserved Domains (3) summary
      COG5576
      Location:274417
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:328385
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:430476
      Homez; Homeodomain leucine-zipper encoding, Homez
    2. NM_001425853.1NP_001412782.1  homeobox and leucine zipper protein Homez isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116591
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
    3. NM_001425855.1NP_001412784.1  homeobox and leucine zipper protein Homez isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116591
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
    4. NM_001425856.1NP_001412785.1  homeobox and leucine zipper protein Homez isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116591
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
    5. NM_183174.3NP_898997.2  homeobox and leucine zipper protein Homez isoform 1

      See identical proteins and their annotated locations for NP_898997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116591, BC094669
      Consensus CDS
      CCDS27102.1
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
      UniProtKB/TrEMBL
      A0A0R4J108
      Related
      ENSMUSP00000079929.6, ENSMUST00000081162.6
      Conserved Domains (3) summary
      COG5576
      Location:274417
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:328385
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:430476
      Homez; Homeodomain leucine-zipper encoding, Homez

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55090193..55109285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518978.5XP_006519041.1  homeobox and leucine zipper protein Homez isoform X3

      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
      Conserved Domains (3) summary
      COG5576
      Location:313456
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:367424
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:469515
      Homez; Homeodomain leucine-zipper encoding, Homez