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    Faim Fas apoptotic inhibitory molecule [ Mus musculus (house mouse) ]

    Gene ID: 23873, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Faimprovided by MGI
    Official Full Name
    Fas apoptotic inhibitory moleculeprovided by MGI
    Primary source
    MGI:MGI:1344387
    See related
    Ensembl:ENSMUSG00000032463 AllianceGenome:MGI:1344387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm. Is expressed in several structures, including gonad; hemolymphoid system; intestine; liver; and retina. Orthologous to human FAIM (Fas apoptotic inhibitory molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.2), CNS E14 (RPKM 8.8) and 24 other tissues See more
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    Genomic context

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    See Faim in Genome Data Viewer
    Location:
    9 E3.3; 9 51.41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (98868426..98884076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (98986373..99002019)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene forkhead box L2, opposite strand Neighboring gene forkhead box L2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:98886571-98886872 Neighboring gene predicted gene 1123 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Neighboring gene STARR-seq mESC enhancer starr_25010 Neighboring gene predicted gene 2773

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina. Sirés A, et al. J Neurosci Res, 2021 Dec. PMID 34713467
    2. Receptor-specific regulation of B-cell susceptibility to Fas-mediated apoptosis and a novel Fas apoptosis inhibitory molecule. Rothstein TL, et al. Immunol Rev, 2000 Aug. PMID 11043772
    3. An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain. Zhong X, et al. Mol Immunol, 2001 Jan. PMID 11483211
    4. Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain. Hemond M, et al. J Mol Biol, 2009 Mar 6. PMID 19168072, Free PMC Article
    5. The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina. Sirés A, et al. Cells, 2023 Feb 2. PMID 36766830, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina.
      Title: The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina.
    2. PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRbeta axis during overnutrition.
      Title: PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition.
    3. Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina.
      Title: Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina.
    4. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
      Title: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
    5. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal.
      Title: FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.
    6. Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis.
      Title: Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis.
    7. defined a TCR-induced FAIM/Akt/Nur77 signaling axis that is critical for modulating the apoptosis of developing thymocytes
      Title: Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression.
    8. FAIM is expressed in germinal center B cells, enhances interferon regulatory factor (IRF)4 expression, and is in turn positively regulated through IRF4 in a positive reinforcing (i.e., feed-forward) system.
      Title: Fas apoptosis inhibitory molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism.
    9. FAIM plays a novel role in modulating Fas-mediated apoptosis and acts through influencing the expression of c-FLIP and regulating the physical binding of caspase-8 to Fas.
      Title: Genetic deletion of faim reveals its role in modulating c-FLIP expression during CD95-mediated apoptosis of lymphocytes and hepatocytes.
    10. The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich.
      Title: Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fas apoptotic inhibitory molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122851.1 → NP_001116323.1  fas apoptotic inhibitory molecule 1 isoform Faim-L

      See identical proteins and their annotated locations for NP_001116323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (Faim-L).
      Source sequence(s)
      BC079662, BU962258
      Consensus CDS
      CCDS52897.1
      UniProtKB/TrEMBL
      A0A087WRH2, D3Z3C1
      Related
      ENSMUSP00000108532.3, ENSMUST00000112911.9
      Conserved Domains (1) summary
      pfam06905
      Location:24 → 198
      FAIM1; Fas apoptotic inhibitory molecule (FAIM1)

    2. NM_011810.3 → NP_035940.3  fas apoptotic inhibitory molecule 1 isoform Faim-S

      See identical proteins and their annotated locations for NP_035940.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the exon containing the translation start codon compared to variant 1. The resulting isoform (Faim-S) has a shorter N-terminus compared to isoform Faim-L.
      Source sequence(s)
      BC079662, BU962258, BY055691
      Consensus CDS
      CCDS23431.1
      UniProtKB/Swiss-Prot
      Q9DAK6, Q9WUD8
      UniProtKB/TrEMBL
      A0A087WRH2
      Related
      ENSMUSP00000035038.2, ENSMUST00000035038.8
      Conserved Domains (1) summary
      pfam06905
      Location:3 → 174
      FAIM1; Fas apoptotic inhibitory molecule (FAIM1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      98868426..98884076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154930.1 → XP_036010823.1  fas apoptotic inhibitory molecule 1 isoform X1

      UniProtKB/TrEMBL
      A0A087WRH2, D3Z3C1
      Conserved Domains (1) summary
      pfam06905
      Location:24 → 198
      FAIM1; Fas apoptotic inhibitory molecule (FAIM1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUD8.1 GenPept UniProtKB/Swiss-Prot:Q9WUD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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