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    Adam6b a disintegrin and metallopeptidase domain 6B [ Mus musculus (house mouse) ]

    Gene ID: 238405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam6bprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 6Bprovided by MGI
    Primary source
    MGI:MGI:2444636
    See related
    Ensembl:ENSMUSG00000051804 AllianceGenome:MGI:2444636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930523C11Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Adam6b in Genome Data Viewer
    Location:
    12 F1; 12 62.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113453185..113455455)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113489565..113491835)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy chain complex Neighboring gene immunoglobulin heavy diversity 6-1 Neighboring gene immunoglobulin heavy diversity 1-1 Neighboring gene immunoglobulin heavy diversity 3-1 Neighboring gene immunoglobulin heavy diversity 5-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    2. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metalloproteinase domain 6-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005838.1 

      Range
      241969..244239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001009545.1 → NP_001009545.1  a disintegrin and metalloproteinase domain 6-like

      See identical proteins and their annotated locations for NP_001009545.1

      Status: VALIDATED

      Source sequence(s)
      BK001467
      Consensus CDS
      CCDS26207.1
      UniProtKB/TrEMBL
      Q14DT8, Q6IMH7
      Related
      ENSMUSP00000065529.3, ENSMUST00000063317.4
      Conserved Domains (4) summary
      smart00608
      Location:503 → 637
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:217 → 406
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:427 → 500
      Disintegrin; Disintegrin
      pfam01562
      Location:69 → 166
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113453185..113455455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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