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    FOSB FosB proto-oncogene, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 2354, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FOSBprovided by HGNC
    Official Full Name
    FosB proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:3797
    See related
    Ensembl:ENSG00000125740 MIM:164772; AllianceGenome:HGNC:3797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP-1; G0S3; GOS3; GOSB
    Summary
    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in gall bladder (RPKM 202.0), bone marrow (RPKM 136.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FOSB in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45467996..45475179)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48295244..48302427)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45971254..45978437)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit G Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45923066-45923566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14796 Neighboring gene Sharpr-MPRA regulatory region 13779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10765 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45943151-45943650 Neighboring gene microRNA 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45958106-45959072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45959073-45960039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45967946-45968446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45968447-45968947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45971355-45972256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14799 Neighboring gene tRNA-SeC (anticodon TCA) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10773 Neighboring gene reticulon 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulatory effects of ΔFosB on proliferation and apoptosis of MCF-7 breast cancer cells. Li H, et al. Tumour Biol, 2016 May. PMID 26608367
    2. Identification of an active gene by using large-scale cDNA sequencing. Itoh K, et al. Gene, 1994 Mar 25. PMID 8144043
    3. Association of FOSB exon 4 unmethylation with poor prognosis in patients with late‑stage non‑small cell lung cancer. Kim DS, et al. Oncol Rep, 2020 Feb. PMID 31894310
    4. Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells. Park JA, et al. Mol Cells, 2019 Dec 31. PMID 31735020, Free PMC Article
    5. FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia). Ortins-Pina A, et al. J Cutan Pathol, 2018 Jun. PMID 29527734

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.
      Title: 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.
    2. Lack of FOS/FOSB Gene Rearrangements in Ischemic Fasciitis Indicates Distinct Pathogenesis from Proliferative Fasciitis and Proliferative Myositis.
      Title: Lack of FOS/FOSB Gene Rearrangements in Ischemic Fasciitis Indicates Distinct Pathogenesis from Proliferative Fasciitis and Proliferative Myositis.
    3. New kids on the block: FOS and FOSB gene.
      Title: New kids on the block: FOS and FOSB gene.
    4. NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.
      Title: NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.
    5. Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells.
      Title: Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells.
    6. Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation.
      Title: Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation.
    7. Inflammatory lobular hemangioma (T-cell-rich angiomatoid polypoid pseudolymphoma)-Assessment of FOS/FOSB and lymphoid markers and comparison with epithelioid hemangioma.
      Title: Inflammatory lobular hemangioma (T-cell-rich angiomatoid polypoid pseudolymphoma)-Assessment of FOS/FOSB and lymphoid markers and comparison with epithelioid hemangioma.
    8. [The Prognostic Value of FOSB Gene in Acute Myeloid Leukemia].
      Title: [The Prognostic Value of FOSB Gene in Acute Myeloid Leukemia].
    9. Knockout of FosB gene changes drug sensitivity and invasion activity via the regulation of Bcl-2, E-cadherin, beta-catenin, and vimentin expression.
      Title: Knockout of FosB gene changes drug sensitivity and invasion activity via the regulation of Bcl-2, E-cadherin, β-catenin, and vimentin expression.
    10. MicroRNA-27a-3p directly targets FosB to regulate cell proliferation, apoptosis, and inflammation responses in immunoglobulin a nephropathy.
      Title: MicroRNA-27a-3p directly targets FosB to regulate cell proliferation, apoptosis, and inflammation responses in immunoglobulin a nephropathy.
    Submit: New GeneRIF Correction See all GeneRIFs (53)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC42291, DKFZp686C0818

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FosB
    Names
    FBJ murine osteosarcoma viral oncogene homolog B
    FosB proto-oncogene, AP-1 trancription factor subunit
    G0/G1 switch regulatory protein 3
    activator protein 1
    transcription factor AP-1 subunit FosB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029675.1 RefSeqGene

      Range
      5002..12185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001114171.2 → NP_001107643.1  protein FosB isoform 2

      See identical proteins and their annotated locations for NP_001107643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an inframe coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC138128, DA589470, DB275824, EU178109
      Consensus CDS
      CCDS46113.1
      UniProtKB/TrEMBL
      Q6FGK6
      Related
      ENSP00000407207.1, ENST00000417353.6
      Conserved Domains (1) summary
      cl21462
      Location:150 → 182
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_001411069.1 → NP_001397998.1  protein FosB isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The resulting isoform (3) lacks the 3' terminal coding segment, as compared to isoform 1.
      Source sequence(s)
      AC138128
      Consensus CDS
      CCDS92643.1
      Related
      ENSP00000465552.1, ENST00000592436.5

    3. NM_006732.3 → NP_006723.2  protein FosB isoform 1

      See identical proteins and their annotated locations for NP_006723.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC138128, BC036724, DA589470, DB275824
      Consensus CDS
      CCDS12664.1
      UniProtKB/Swiss-Prot
      A8K9K5, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7, A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, K7EKC1, K7EMJ6, P53539, Q49AD7
      UniProtKB/TrEMBL
      Q6FGK6
      Related
      ENSP00000245919.3, ENST00000353609.8
      Conserved Domains (1) summary
      cd14721
      Location:165 → 218
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      45467996..45475179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438550.1 → XP_047294506.1  protein FosB isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48295244..48302427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320409.1 → XP_054176384.1  protein FosB isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53539.1 GenPept UniProtKB/Swiss-Prot:P53539

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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