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    Cpa2 carboxypeptidase A2, pancreatic [ Mus musculus (house mouse) ]

    Gene ID: 232680, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cpa2provided by MGI
    Official Full Name
    carboxypeptidase A2, pancreaticprovided by MGI
    Primary source
    MGI:MGI:3617840
    See related
    Ensembl:ENSMUSG00000071553 AllianceGenome:MGI:3617840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed by the pancreatic exocrine cells which secrete the enzyme during digestion. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in spleen adult (RPKM 67.2), small intestine adult (RPKM 62.2) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpa2 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30541641..30564475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30541642..30564476)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 209 Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A4 Neighboring gene predicted gene, 31453

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage. Desanlis I, et al. J Dev Biol, 2020 Dec 7. PMID 33297480, Free PMC Article
    2. The single-cell transcriptional landscape of mammalian organogenesis. Cao J, et al. Nature, 2019 Feb. PMID 30787437, Free PMC Article
    3. p27 Regulates the transition of beta-cells from quiescence to proliferation. Georgia S, et al. Diabetes, 2006 Nov. PMID 17065330
    4. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. Wells JM, et al. BMC Dev Biol, 2007 Jan 12. PMID 17222338, Free PMC Article
    5. Conditional ablation of Notch signaling in pancreatic development. Nakhai H, et al. Development, 2008 Aug. PMID 18635610

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107514

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase A2
    NP_001019869.1
    XP_011239359.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024698.3 → NP_001019869.1  carboxypeptidase A2 preproprotein

      See identical proteins and their annotated locations for NP_001019869.1

      Status: REVIEWED

      Source sequence(s)
      BB610349, BP772440, CO428705
      Consensus CDS
      CCDS19974.1
      UniProtKB/Swiss-Prot
      Q504N0
      Related
      ENSMUSP00000093771.5, ENSMUST00000096066.5
      Conserved Domains (2) summary
      cd03870
      Location:116 → 415
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:27 → 99
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30541641..30564475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241057.2 → XP_011239359.1  carboxypeptidase A2 isoform X1

      Conserved Domains (1) summary
      cd03870
      Location:13 → 312
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q504N0.1 GenPept UniProtKB/Swiss-Prot:Q504N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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