Clec12a C-type lectin domain family 12, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec12aprovided by MGI
Official Full Name: C-type lectin domain family 12, member aprovided by MGI
Primary source: MGI:MGI:3040968
See related: Ensembl:ENSMUSG00000053063 AllianceGenome:MGI:3040968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Micl; CLL-1; KLRL1; mMICL; mKLRL1; D230024O04
Summary: Predicted to enable protein phosphatase binding activity and transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within regulation of immune response. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 6.7), liver E14 (RPKM 4.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.26 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129327207..129342266)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129349783..129365303)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recognition and control of neutrophil extracellular trap formation by MICL.
Title: Recognition and control of neutrophil extracellular trap formation by MICL.
Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.
Title: Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.
The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.
Title: The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.
Study observed that the uric acid crystal receptor Clec12A functions as a positive modulator of the IFN-I response, which amplifies nucleic acid-sensing pattern recognition receptors signals through the TBK1-IRF3 axis. Clec12a-/- mice exhibit increased susceptibility to acute lymphocytic choriomeningitis virus (LCMV) infection and improved virus clearance during chronic LCMV infection in vivo.
Title: The uric acid crystal receptor Clec12A potentiates type I interferon responses.
The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS.
Title: Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting
Title: Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.
Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo.
Title: Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
Title: Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia
Title: The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.
Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent
Title: The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor regulator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of natural killer cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 12 member A

Names: C-type lectin-like molecule 1; killer cell C-type lectin-like receptor L1; myeloid inhibitory C-type lectin-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177686.4 → NP_808354.1 C-type lectin domain family 12 member A

See identical proteins and their annotated locations for NP_808354.1

Status: VALIDATED

Source sequence(s)

AC138620, AK084335, BB850261

Consensus CDS

CCDS20584.1

UniProtKB/Swiss-Prot

Q504P2, Q8BN96

UniProtKB/TrEMBL

A0A0R4J0T2

Related

ENSMUSP00000063627.5, ENSMUST00000065289.6

Conserved Domains (1) summary

cd03593
Location:133 → 247

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)