Radil Ras association and DIL domains [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Radilprovided by MGI
Official Full Name: Ras association and DIL domainsprovided by MGI
Primary source: MGI:MGI:2443088
See related: Ensembl:ENSMUSG00000029576 AllianceGenome:MGI:2443088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D930005D10Rik
Summary: Predicted to enable GTPase binding activity. Predicted to be involved in neural crest cell migration and substrate adhesion-dependent cell spreading. Predicted to be part of protein-containing complex. Predicted to be active in microtubule. Is expressed in testis. Orthologous to human RADIL (Rap associating with DIL domain). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 12.8), lung adult (RPKM 12.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.53 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142470594..142536873, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142483795..142551098, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D5Mit222 (e-PCR), detects polymorphism
- UniSTS:130354

Papolb (e-PCR), detects polymorphism
- UniSTS:526975

AI536456 (e-PCR)
- UniSTS:164306

Radil (e-PCR), detects polymorphism
- UniSTS:532472

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-associating and dilute domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289588.1 → NP_001276517.1 ras-associating and dilute domain-containing protein isoform 1

See identical proteins and their annotated locations for NP_001276517.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AI536456, AK162917, BY201066

Consensus CDS

CCDS71698.1

UniProtKB/TrEMBL

D3YWJ9

Related

ENSMUSP00000106412.2, ENSMUST00000110785.2

Conserved Domains (4) summary

cd00992
Location:992 → 1076

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:411 → 778

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

cd17116
Location:50 → 161

RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins

pfam00498
Location:273 → 343

FHA; FHA domain
NM_001310752.1 → NP_001297681.1 ras-associating and dilute domain-containing protein isoform 3

See identical proteins and their annotated locations for NP_001297681.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AI536456, AK052964, AK083410

Consensus CDS

CCDS80453.1

UniProtKB/Swiss-Prot

Q69Z89, Q8BNL0, Q8C549, Q8C6X2, Q8CAL1

Related

ENSMUSP00000082910.4, ENSMUST00000085758.10

Conserved Domains (4) summary

cd00992
Location:998 → 1082

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:440 → 807

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:302 → 372

FHA; FHA domain

pfam00788
Location:90 → 193

RA; Ras association (RalGDS/AF-6) domain
NM_178702.4 → NP_848817.2 ras-associating and dilute domain-containing protein isoform 2

See identical proteins and their annotated locations for NP_848817.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site inthe 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AI536456, BC056483, BY201066

Consensus CDS

CCDS19827.1

UniProtKB/Swiss-Prot

Q69Z89

Related

ENSMUSP00000064539.9, ENSMUST00000063635.15

Conserved Domains (4) summary

cd00992
Location:969 → 1053

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:411 → 778

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:273 → 343

FHA; FHA domain

pfam00788
Location:61 → 164

RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

142470594..142536873 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504685.5 → XP_006504748.1 ras-associating and dilute domain-containing protein isoform X2

See identical proteins and their annotated locations for XP_006504748.1

UniProtKB/TrEMBL

D3YWJ9

Conserved Domains (4) summary

cd00992
Location:992 → 1076

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:411 → 778

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

cd17116
Location:50 → 161

RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins

pfam00498
Location:273 → 343

FHA; FHA domain
XM_006504682.4 → XP_006504745.1 ras-associating and dilute domain-containing protein isoform X1

Conserved Domains (4) summary

cd00992
Location:1021 → 1105

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:440 → 807

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

cd17116
Location:79 → 190

RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins

pfam00498
Location:302 → 372

FHA; FHA domain
XM_030254449.2 → XP_030110309.1 ras-associating and dilute domain-containing protein isoform X5

Conserved Domains (2) summary

cd00992
Location:475 → 559

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:1 → 284

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
XM_030254445.2 → XP_030110305.1 ras-associating and dilute domain-containing protein isoform X3

Conserved Domains (3) summary

cd00992
Location:752 → 836

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:171 → 538

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:33 → 103

FHA; FHA domain
XM_030254446.2 → XP_030110306.1 ras-associating and dilute domain-containing protein isoform X3

Conserved Domains (3) summary

cd00992
Location:752 → 836

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:171 → 538

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:33 → 103

FHA; FHA domain
XM_006504686.4 → XP_006504749.1 ras-associating and dilute domain-containing protein isoform X4

See identical proteins and their annotated locations for XP_006504749.1

UniProtKB/Swiss-Prot

Q69Z89

Related

ENSMUSP00000106411.2, ENSMUST00000110784.8

Conserved Domains (3) summary

cd00992
Location:729 → 813

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:171 → 538

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:33 → 103

FHA; FHA domain
XM_030254447.2 → XP_030110307.1 ras-associating and dilute domain-containing protein isoform X4

Conserved Domains (3) summary

cd00992
Location:729 → 813

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:171 → 538

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:33 → 103

FHA; FHA domain
XM_030254444.2 → XP_030110304.1 ras-associating and dilute domain-containing protein isoform X3

Conserved Domains (3) summary

cd00992
Location:752 → 836

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:171 → 538

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00498
Location:33 → 103

FHA; FHA domain