Plac8 placenta-specific 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plac8provided by MGI
Official Full Name: placenta-specific 8provided by MGI
Primary source: MGI:MGI:2445289
See related: Ensembl:ENSMUSG00000029322 AllianceGenome:MGI:2445289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C15; D5Wsu111e
Summary: Enables chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of transcription by RNA polymerase II; and response to cold. Predicted to be located in nucleoplasm. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver lobe; and prostate gland lobe. Orthologous to human PLAC8 (placenta associated 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 141.6), large intestine adult (RPKM 140.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E4; 5 48.49 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (100699455..100720119, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (100551589..100572253, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.
Title: PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.
Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
Title: Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
Results establish PLAC8 as a central mediator of tumor progression in PDAC.
Title: PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways.
Plac8 provides a mechanistic link between primary oncogenic mutations and the induction of autophagy, a central mechanism of metabolic reprogramming, during PDA progression.
Title: Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.
Plac8 is an upstream regulator of C/EBPbeta required for adipogenesis in vitro. In vivo, Plac8 is dispensable for the differentiation of white adipocytes with preserved fat storage capacity but is required for normal fat cell count regulation
Title: Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo.
Data indicate that dampened contact hypersensitivity (CHS) responses correlated with a significant reduction in pro-inflammatory IL-6 at the challenge site in ONZIN-deficient animals.
Title: ONZIN deficiency attenuates contact hypersensitivity responses in mice.
These results demonstrate that there are two independent and redundant T cell mechanisms for clearing C. muridarum genital tract infections: one dependent on iNOS, and the other dependent on Plac8.
Title: Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract.
These findings demonstrate a functional interdependence between onzin and PLSCR1.
Title: The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1.
results identify onzin as a novel regulator of several p53-dependent aspects of the c-Myc phenotype via its dramatic effect on Mdm2
Title: Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.
ONZIN as a novel class of intracellular protein required for optimal function of the neutrophils after uptake of bacteria.
Title: Impaired host defense in mice lacking ONZIN.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:463464 (e-PCR)
- UniSTS:463464

Plac8 (e-PCR), detects polymorphism
- UniSTS:463464

RH125762 (e-PCR)
- UniSTS:142565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: placenta-specific gene 8 protein

Names: onzin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370754.1 → NP_001357683.1 placenta-specific gene 8 protein

Status: VALIDATED

Source sequence(s)

AC109196

Consensus CDS

CCDS19464.1

UniProtKB/Swiss-Prot

Q9JI48

Related

ENSMUSP00000108531.2, ENSMUST00000112910.2

Conserved Domains (1) summary

TIGR01571
Location:21 → 105

A_thal_Cys_rich; uncharacterized Cys-rich domain
NM_139198.3 → NP_631937.1 placenta-specific gene 8 protein

See identical proteins and their annotated locations for NP_631937.1

Status: VALIDATED

Source sequence(s)

AC109196

Consensus CDS

CCDS19464.1

UniProtKB/Swiss-Prot

Q9JI48

Related

ENSMUSP00000031264.6, ENSMUST00000031264.12

Conserved Domains (1) summary

TIGR01571
Location:21 → 105

A_thal_Cys_rich; uncharacterized Cys-rich domain