Foxj3 forkhead box J3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxj3provided by MGI
Official Full Name: forkhead box J3provided by MGI
Primary source: MGI:MGI:2443432
See related: Ensembl:ENSMUSG00000032998 AllianceGenome:MGI:2443432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fhd6; C330039G02Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male meiosis I and spermatogenesis. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human FOXJ3 (forkhead box J3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 9.4), whole brain E14.5 (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 55.43 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (119396858..119486316)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (119539661..119629119)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1alpha.
Title: Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1α.
FOXJ3 is required for the survival of spermatogonia and participates in spermatocyte meiosis.
Title: Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.
Data suggest that microRNA 494 regulates mitochondrial biogenesis by down-regulating mtTFA (mitochondrial transcription factor A) and Foxj3 (forkhead box J3 protein) during myocyte differentiation and skeletal muscle adaptation to physical exercise.
Title: MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3.
Foxj3 is an important regulator of myofiber identity and muscle regeneration through the transcriptional activation of the Mef2c gene.
Title: Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity.
Data show that developing limbs have a complex pattern of Foxj3 expression that at E12.5 colocalizes with the condensed mesenchyme of the skeletal primordia.
Title: FoxJ3, a novel mammalian forkhead gene expressed in neuroectoderm, neural crest, and myotome.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235015

UniSTS:235016 (e-PCR)
- UniSTS:235016

Foxj3 (e-PCR), detects polymorphism
- UniSTS:532316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein J3

Names: forkhead domain gene 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290696.1 → NP_001277625.1 forkhead box protein J3 isoform 2

See identical proteins and their annotated locations for NP_001277625.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AK077346, AK082840, BP763140, CB245622, CJ048244

Consensus CDS

CCDS71462.1

UniProtKB/Swiss-Prot

Q8BUR3

Related

ENSMUSP00000101917.3, ENSMUST00000106310.9

Conserved Domains (2) summary

pfam15258
Location:332 → 404

FAM222A; Protein family of FAM222A

cd20024
Location:78 → 154

FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins
NM_001357177.1 → NP_001344106.1 forkhead box protein J3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK077346, AK082840, AK139508, AL645563, BP763140

Consensus CDS

CCDS18585.1

UniProtKB/Swiss-Prot

A2AA37, A2AA38, Q3UTD8, Q8BUR3

Conserved Domains (3) summary

COG5025
Location:54 → 347

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam00250
Location:78 → 155

Forkhead; Forkhead domain

pfam09770
Location:311 → 434

PAT1; Topoisomerase II-associated protein PAT1
NM_172699.3 → NP_766287.1 forkhead box protein J3 isoform 1

See identical proteins and their annotated locations for NP_766287.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer isoform (1). Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK077346, AK082840, AK139508, BP763140

Consensus CDS

CCDS18585.1

UniProtKB/Swiss-Prot

A2AA37, A2AA38, Q3UTD8, Q8BUR3

Related

ENSMUSP00000035746.9, ENSMUST00000044564.15

Conserved Domains (3) summary

COG5025
Location:54 → 347

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam00250
Location:78 → 155

Forkhead; Forkhead domain

pfam09770
Location:311 → 434

PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

119396858..119486316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503017.5 → XP_006503080.1 forkhead box protein J3 isoform X1

See identical proteins and their annotated locations for XP_006503080.1

UniProtKB/Swiss-Prot

A2AA37, A2AA38, Q3UTD8, Q8BUR3

Conserved Domains (3) summary

COG5025
Location:54 → 347

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam00250
Location:78 → 155

Forkhead; Forkhead domain

pfam09770
Location:311 → 434

PAT1; Topoisomerase II-associated protein PAT1
XM_036164038.1 → XP_036019931.1 forkhead box protein J3 isoform X2

Conserved Domains (2) summary

pfam15258
Location:332 → 404

FAM222A; Protein family of FAM222A

cd20024
Location:78 → 154

FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins
XM_036164039.1 → XP_036019932.1 forkhead box protein J3 isoform X2

Conserved Domains (2) summary

pfam15258
Location:332 → 404

FAM222A; Protein family of FAM222A

cd20024
Location:78 → 154

FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins