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    Actr1b ARP1 actin-related protein 1B, centractin beta [ Mus musculus (house mouse) ]

    Gene ID: 226977, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Actr1bprovided by MGI
    Official Full Name
    ARP1 actin-related protein 1B, centractin betaprovided by MGI
    Primary source
    MGI:MGI:1917446
    See related
    Ensembl:ENSMUSG00000037351 AllianceGenome:MGI:1917446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp1b; 2310066K23Rik
    Summary
    Predicted to enable ATP binding activity. Predicted to be located in centrosome and cytoplasm. Predicted to be part of dynactin complex. Is expressed in olfactory epithelium and vomeronasal organ. Orthologous to human ACTR1B (actin related protein 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 55.7), cerebellum adult (RPKM 47.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Actr1b in Genome Data Viewer
    Location:
    1 B; 1 15.38 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36737195..36749051, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36698114..36710017, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 178, member B Neighboring gene STARR-seq mESC enhancer starr_00646 Neighboring gene RIKEN cDNA 4933424G06 gene Neighboring gene STARR-positive B cell enhancer ABC_E1539 Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene predicted gene, 33533 Neighboring gene predicted gene, 18828 Neighboring gene zeta-chain (TCR) associated protein kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of the actin family. Goodson HV, et al. J Cell Sci, 2002 Jul 1. PMID 12077353
    2. Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. Sacksteder CA, et al. Biochemistry, 2006 Jul 4. PMID 16800626
    3. Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. O'Brien R, et al. J Biol Chem, 2015 Jul 31. PMID 26025364, Free PMC Article
    4. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Gorini G, et al. FEBS Lett, 2010 Mar 5. PMID 20114047, Free PMC Article
    5. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Maurice P, et al. Mol Cell Proteomics, 2008 Aug. PMID 18448421, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36526

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-centractin
    Names
    ARP1 actin-related protein 1 homolog B, centractin beta
    actin-related protein 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418135.1 → NP_001405064.1  beta-centractin isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084389

    2. NM_001418136.1 → NP_001405065.1  beta-centractin isoform c

      Status: VALIDATED

      Source sequence(s)
      AC084389

    3. NM_001418137.1 → NP_001405066.1  beta-centractin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC084389

    4. NM_001418138.1 → NP_001405067.1  beta-centractin isoform e

      Status: VALIDATED

      Source sequence(s)
      AC084389

    5. NM_001418139.1 → NP_001405068.1  beta-centractin isoform e

      Status: VALIDATED

      Source sequence(s)
      AC084389

    6. NM_001418140.1 → NP_001405069.1  beta-centractin isoform e

      Status: VALIDATED

      Source sequence(s)
      AC084389

    7. NM_001418141.1 → NP_001405070.1  beta-centractin isoform e

      Status: VALIDATED

      Source sequence(s)
      AC084389

    8. NM_001418142.1 → NP_001405071.1  beta-centractin isoform f

      Status: VALIDATED

      Source sequence(s)
      AC084389

    9. NM_001418143.1 → NP_001405072.1  beta-centractin isoform g

      Status: VALIDATED

      Source sequence(s)
      AC084389

    10. NM_001418144.1 → NP_001405073.1  beta-centractin isoform h

      Status: VALIDATED

      Source sequence(s)
      AC084389

    11. NM_146107.3 → NP_666219.1  beta-centractin isoform b

      See identical proteins and their annotated locations for NP_666219.1

      Status: VALIDATED

      Source sequence(s)
      AC084389
      Consensus CDS
      CCDS14887.1
      UniProtKB/Swiss-Prot
      Q8R5C5
      Related
      ENSMUSP00000047326.4, ENSMUST00000043951.10
      Conserved Domains (1) summary
      cl17037
      Location:5 → 376
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36737195..36749051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164312.1 → XP_036020205.1  beta-centractin isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1 → 302
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5C5.1 GenPept UniProtKB/Swiss-Prot:Q8R5C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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