Wnt11 wingless-type MMTV integration site family, member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt11provided by MGI
Official Full Name: wingless-type MMTV integration site family, member 11provided by MGI
Primary source: MGI:MGI:101948
See related: Ensembl:ENSMUSG00000015957 AllianceGenome:MGI:101948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable enzyme activator activity and signaling receptor binding activity. Involved in heart development. Acts upstream of or within several processes, including Wnt signaling pathway; circulatory system development; and negative regulation of cell population proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 15.3), limb E14.5 (RPKM 15.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.9 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (98484293..98503954)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (98835084..98854747)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt11 in regulation of physiological and pathological cardiac growth.
Title: Wnt11 in regulation of physiological and pathological cardiac growth.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Title: WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.
Title: Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.
Study utilizing mouse kidney cultures and time-lapse imaging provided quantitative experimental support that a ligand-receptor-based Turing mechanism, implemented via GDNF-RET signaling, specifies the areas of outgrowth during kidney branching morphogenesis. The positive feedback between GDNF and WNT11 enables the dense packing of the ureteric buds.
Title: Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.
These studies revealed a previously unappreciated role for WNT11 for dorsal mesenchymal protrusion (DMP) formation and distinct tissue-specific requirements for WNT11 in outflow tract and DMP development.
Title: Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion.
Wnt4 and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation.
Title: Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
Results provide evidence that Wnt11 is involved in the organization of kidney tubules through the planar cell polarity pathway taking part in fine-tuning of nephrogenesis.
Title: Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.
under tensile stress, miR-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt/PCP pathway by directly targeting Wnt11
Title: MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11.
a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported.
Title: Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression.
Studied groups of embryoid bodies (EBs) with different starting numbers of ESCs & found differential gene expression patterns for Wnt5a & Wnt11. Wnt11 inc'd the percentage of beating EBs by upregulating expression of cardiac-specific genes.
Title: Enrichment of cardiac differentiation by a large starting number of embryonic stem cells in embryoid bodies is mediated by the Wnt11-JNK pathway.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt11 (e-PCR), detects polymorphism
- UniSTS:465416

Wnt11 (e-PCR), detects polymorphism
- UniSTS:465417

Wnt11 (e-PCR), detects polymorphism
- UniSTS:526098

Wnt11 (e-PCR), detects polymorphism
- UniSTS:527133

UniSTS:471854 (e-PCR)
- UniSTS:471854

Wnt11 (e-PCR), detects polymorphism
- UniSTS:471854

Wnt11 (e-PCR), detects polymorphism
- UniSTS:259673

Wnt11 (e-PCR), detects polymorphism
- UniSTS:508506

Wnt11 (e-PCR), detects polymorphism
- UniSTS:508507

X70800 (e-PCR)
- UniSTS:163424

Wnt11 (e-PCR), detects polymorphism
- UniSTS:144774

NoName (e-PCR)
- UniSTS:492238

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial septum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cloacal septation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial to mesenchymal transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within kidney development	IDA Inferred from Direct Assay more info	PubMed
involved_in lung-associated mesenchyme development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephric duct development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuroendocrine cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within paraxial mesoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary heart field specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary heart field specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within somite development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-11

Names: wingless-related MMTV integration site 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285792.1 → NP_001272721.1 protein Wnt-11 isoform a precursor

See identical proteins and their annotated locations for NP_001272721.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC110039, AK031573, AK077828, AK138967

Consensus CDS

CCDS21475.1

UniProtKB/Swiss-Prot

P48615

UniProtKB/TrEMBL

Q059Y4

Related

ENSMUSP00000064333.3, ENSMUST00000067495.9

Conserved Domains (1) summary

cd19343
Location:51 → 354

Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins
NM_001285794.1 → NP_001272723.1 protein Wnt-11 isoform b

See identical proteins and their annotated locations for NP_001272723.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AK031573, AK138967

UniProtKB/TrEMBL

Q3UTY8

Conserved Domains (1) summary

pfam00110
Location:1 → 289

wnt; wnt family
NM_001285795.1 → NP_001272724.1 protein Wnt-11 isoform c

See identical proteins and their annotated locations for NP_001272724.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC110039, AK031573, BC125482

UniProtKB/TrEMBL

Q059Y4

Conserved Domains (1) summary

cl38924
Location:32 → 185

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
NM_009519.2 → NP_033545.1 protein Wnt-11 isoform a precursor

See identical proteins and their annotated locations for NP_033545.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC110039, BC125484

Consensus CDS

CCDS21475.1

UniProtKB/Swiss-Prot

P48615

UniProtKB/TrEMBL

Q059Y4

Related

ENSMUSP00000132166.2, ENSMUST00000167303.8

Conserved Domains (1) summary

cd19343
Location:51 → 354

Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

98484293..98503954

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507587.5 → XP_006507650.1 protein Wnt-11 isoform X3

See identical proteins and their annotated locations for XP_006507650.1

Conserved Domains (1) summary

cl38924
Location:32 → 185

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
XM_006507586.5 → XP_006507649.1 protein Wnt-11 isoform X1

See identical proteins and their annotated locations for XP_006507649.1

UniProtKB/Swiss-Prot

P48615

UniProtKB/TrEMBL

Q059Y4

Conserved Domains (1) summary

cd19343
Location:51 → 354

Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins
XM_011241733.2 → XP_011240035.1 protein Wnt-11 isoform X2

Conserved Domains (1) summary

cd19343
Location:69 → 223

Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins