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    Itga10 integrin, alpha 10 [ Mus musculus (house mouse) ]

    Gene ID: 213119, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Itga10provided by MGI
    Official Full Name
    integrin, alpha 10provided by MGI
    Primary source
    MGI:MGI:2153482
    See related
    Ensembl:ENSMUSG00000090210 AllianceGenome:MGI:2153482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630048L14
    Summary
    Predicted to enable collagen binding activity involved in cell-matrix adhesion and integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to be part of integrin alpha10-beta1 complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; hindlimb; sensory organ; and skeleton. Orthologous to human ITGA10 (integrin subunit alpha 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 8.9), CNS E14 (RPKM 2.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itga10 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96552900..96571835)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96645584..96664519)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene RNA binding motif protein 8a Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene ribosomal protein L21, pseudogene 11 Neighboring gene STARR-positive B cell enhancer ABC_E6084 Neighboring gene STARR-seq mESC enhancer starr_08444 Neighboring gene ankyrin repeat domain 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiscale anisotropy analysis of second-harmonic generation collagen imaging of mouse skin. Tilbury K, et al. J Biomed Opt, 2021 Jun. PMID 34159763, Free PMC Article
    2. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors. Engel BE, et al. Cell Death Dis, 2013 Nov 28. PMID 24287699, Free PMC Article
    3. Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants. Bengtsson T, et al. Matrix Biol, 2001 Dec. PMID 11731273
    4. BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes. Gouttenoire J, et al. Eur J Cell Biol, 2010 Apr. PMID 20129696, Free PMC Article
    5. The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens. Popova SN, et al. Dev Biol, 2004 Jun 15. PMID 15183724

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors.
      Title: Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors.
    2. The relative expressions of alpha 10 integrin subunits are good markers to define the differentiation state of chondrocytes.
      Title: BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes.
    3. integrin alpha10beta1 plays a specific role in growth plate morphogenesis and function
      Title: Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Potential readthrough

    Included gene: Pex11b

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding involved in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin alpha10-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-10
    Names
    integrin subunit alpha10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302471.1 → NP_001289400.1  integrin alpha-10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112261, AC122037
      Consensus CDS
      CCDS38557.2
      UniProtKB/TrEMBL
      E9PXZ3, E9Q6R1, Q14BL5
      Related
      ENSMUSP00000112393.2, ENSMUST00000119365.8
      Conserved Domains (3) summary
      smart00191
      Location:545 → 599
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:166 → 346
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:642 → 1049
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96552900..96571835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081053.1: Suppressed sequence

      Description
      NM_001081053.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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