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    Sele selectin, endothelial cell [ Mus musculus (house mouse) ]

    Gene ID: 20339, updated on 27-Nov-2024

    Summary

    Official Symbol
    Seleprovided by MGI
    Official Full Name
    selectin, endothelial cellprovided by MGI
    Primary source
    MGI:MGI:98278
    See related
    Ensembl:ENSMUSG00000026582 AllianceGenome:MGI:98278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Elam; CD62E; ELAM-1; LECAM2; E-selectin
    Summary
    Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte migration. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including adrenal gland; genitourinary system; incisor; integumental system; and limb segment. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 5.9), placenta adult (RPKM 2.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Sele in Genome Data Viewer
    Location:
    1 H2.2; 1 71.35 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163867200..163886056)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164039614..164058487)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene STARR-seq mESC enhancer starr_02860 Neighboring gene methyltransferase like 18 Neighboring gene STARR-seq mESC enhancer starr_02864 Neighboring gene STARR-positive B cell enhancer ABC_E7768 Neighboring gene STARR-positive B cell enhancer ABC_E3322 Neighboring gene STARR-positive B cell enhancer ABC_E10052 Neighboring gene STARR-positive B cell enhancer ABC_E7769 Neighboring gene STARR-positive B cell enhancer ABC_E11099 Neighboring gene STARR-positive B cell enhancer ABC_E11100 Neighboring gene STARR-positive B cell enhancer ABC_E9063 Neighboring gene selectin, lymphocyte Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:166065744-166065853 Neighboring gene STARR-positive B cell enhancer ABC_E2579 Neighboring gene STARR-positive B cell enhancer ABC_E4370 Neighboring gene selectin, platelet Neighboring gene predicted gene 16548

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sialic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament-based process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte tethering or rolling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E-selectin
    Names
    CD62 antigen-like family member E
    endothelial leukocyte adhesion molecule 1
    leukocyte-endothelial cell adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011345.3NP_035475.2  E-selectin precursor

      Status: VALIDATED

      Source sequence(s)
      AC110499
      Consensus CDS
      CCDS15432.1
      UniProtKB/Swiss-Prot
      Q00690
      Related
      ENSMUSP00000027874.7, ENSMUST00000027874.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      163867200..163886056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319404.3XP_017174893.1  E-selectin isoform X2

      Conserved Domains (4) summary
      cd00033
      Location:501556
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:29147
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      PHA02927
      Location:269496
      PHA02927; secreted complement-binding protein; Provisional
      cd00054
      Location:155182
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. XM_006496715.4XP_006496778.1  E-selectin isoform X1

      See identical proteins and their annotated locations for XP_006496778.1

      UniProtKB/TrEMBL
      Q3U5F6
      Conserved Domains (4) summary
      cd00033
      Location:501556
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:29147
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      PHA02927
      Location:269496
      PHA02927; secreted complement-binding protein; Provisional
      cd00054
      Location:155182
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...