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    FYB2 FYN binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 199920, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FYB2provided by HGNC
    Official Full Name
    FYN binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:27295
    See related
    Ensembl:ENSG00000187889 MIM:618478; AllianceGenome:HGNC:27295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARAP; C1orf168
    Summary
    Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver (RPKM 2.0), kidney (RPKM 0.9) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FYB2 in Genome Data Viewer
    Location:
    1p32.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (56718789..56826914, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (56597656..56710605, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (57184462..57285077, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 85 Neighboring gene uncharacterized LOC101929935 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 2 Neighboring gene NANOG hESC enhancer GRCh37_chr1:57230284-57230838 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8694 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1079 Neighboring gene complement C8 alpha chain Neighboring gene Sharpr-MPRA regulatory region 9770 Neighboring gene uncharacterized LOC112267900 Neighboring gene complement C8 beta chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. Qi Q, et al. Hum Mol Genet, 2012 Nov 1. PMID 22843503, Free PMC Article
    2. ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion. Jung SH, et al. J Immunol, 2016 Aug 1. PMID 27335501
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
    4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
    5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43208

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FYN-binding protein 2
    Names
    RP4-758N20.2
    activation-dependent, raft-recruited ADAP-like phosphoprotein
    uncharacterized protein C1orf168

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004303.5 → NP_001004303.3  FYN-binding protein 2

      See identical proteins and their annotated locations for NP_001004303.3

      Status: VALIDATED

      Source sequence(s)
      AK093468, AL035705, BU686304, BX648439, DA523424, DB193989
      Consensus CDS
      CCDS30729.1
      UniProtKB/Swiss-Prot
      Q5VWT5, Q63HM3, Q6ZUY6
      Related
      ENSP00000345972.6, ENST00000343433.7
      Conserved Domains (1) summary
      cl17036
      Location:647 → 719
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      56718789..56826914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448402.1 → XP_047304358.1  FYN-binding protein 2 isoform X5

    2. XM_047448401.1 → XP_047304357.1  FYN-binding protein 2 isoform X5

    3. XM_047448403.1 → XP_047304359.1  FYN-binding protein 2 isoform X7

    4. XM_005270584.4 → XP_005270641.1  FYN-binding protein 2 isoform X6

      Conserved Domains (1) summary
      cl17036
      Location:539 → 611
      SH3; Src Homology 3 domain superfamily

    5. XM_047448400.1 → XP_047304356.1  FYN-binding protein 2 isoform X3

    6. XM_011540899.2 → XP_011539201.1  FYN-binding protein 2 isoform X2

      Conserved Domains (1) summary
      cl17036
      Location:643 → 715
      SH3; Src Homology 3 domain superfamily

    7. XM_011540898.2 → XP_011539200.1  FYN-binding protein 2 isoform X1

      Conserved Domains (1) summary
      cl17036
      Location:673 → 745
      SH3; Src Homology 3 domain superfamily

    8. XM_011540904.3 → XP_011539206.1  FYN-binding protein 2 isoform X10

      Conserved Domains (1) summary
      cl17036
      Location:365 → 437
      SH3; Src Homology 3 domain superfamily

    9. XM_011540906.4 → XP_011539208.1  FYN-binding protein 2 isoform X12

      Related
      ENST00000493000.5
      Conserved Domains (1) summary
      cl17036
      Location:303 → 375
      SH3; Src Homology 3 domain superfamily

    10. XM_011540903.3 → XP_011539205.1  FYN-binding protein 2 isoform X8

    11. XM_011540900.3 → XP_011539202.1  FYN-binding protein 2 isoform X4

    12. XM_047448410.1 → XP_047304366.1  FYN-binding protein 2 isoform X8

    13. XM_017000548.2 → XP_016856037.1  FYN-binding protein 2 isoform X9

    14. XM_011540905.3 → XP_011539207.1  FYN-binding protein 2 isoform X11

    RNA

    1. XR_007095697.1 RNA Sequence

    2. XR_007095698.1 RNA Sequence

    3. XR_946570.2 RNA Sequence

    4. XR_001737026.2 RNA Sequence

    5. XR_946572.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      56597656..56710605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334879.1 → XP_054190854.1  FYN-binding protein 2 isoform X13

      UniProtKB/Swiss-Prot
      Q5VWT5, Q63HM3, Q6ZUY6

    2. XM_054334884.1 → XP_054190859.1  FYN-binding protein 2 isoform X5

    3. XM_054334883.1 → XP_054190858.1  FYN-binding protein 2 isoform X5

    4. XM_054334886.1 → XP_054190861.1  FYN-binding protein 2 isoform X7

    5. XM_054334885.1 → XP_054190860.1  FYN-binding protein 2 isoform X6

    6. XM_054334881.1 → XP_054190856.1  FYN-binding protein 2 isoform X3

    7. XM_054334880.1 → XP_054190855.1  FYN-binding protein 2 isoform X2

    8. XM_054334878.1 → XP_054190853.1  FYN-binding protein 2 isoform X1

    9. XM_054334890.1 → XP_054190865.1  FYN-binding protein 2 isoform X10

    10. XM_054334892.1 → XP_054190867.1  FYN-binding protein 2 isoform X12

    11. XM_054334888.1 → XP_054190863.1  FYN-binding protein 2 isoform X8

    12. XM_054334882.1 → XP_054190857.1  FYN-binding protein 2 isoform X4

    13. XM_054334887.1 → XP_054190862.1  FYN-binding protein 2 isoform X8

    14. XM_054334889.1 → XP_054190864.1  FYN-binding protein 2 isoform X9

    15. XM_054334891.1 → XP_054190866.1  FYN-binding protein 2 isoform X11

    RNA

    1. XR_008485953.1 RNA Sequence

    2. XR_008485956.1 RNA Sequence

    3. XR_008485954.1 RNA Sequence

    4. XR_008485955.1 RNA Sequence

    5. XR_008485957.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VWT5.1 GenPept UniProtKB/Swiss-Prot:Q5VWT5

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