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    Skint3 selection and upkeep of intraepithelial T cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 195564, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Skint3provided by MGI
    Official Full Name
    selection and upkeep of intraepithelial T cells 3provided by MGI
    Primary source
    MGI:MGI:3045331
    See related
    Ensembl:ENSMUSG00000070868 AllianceGenome:MGI:3045331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Skint-3; A430090E18Rik
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; liver; and thymus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Skint3 in Genome Data Viewer
    Location:
    4 D1; 4 51.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (112089442..112157665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (112232245..112300468)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 1 Neighboring gene STARR-seq mESC enhancer starr_11099 Neighboring gene selection and upkeep of intraepithelial T cells 4 Neighboring gene selection and upkeep of intraepithelial T cells 9 Neighboring gene predicted gene 12819

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Boyden LM, et al. Nat Genet, 2008 May. PMID 18408721, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    selection and upkeep of intraepithelial T-cells protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102474.2 → NP_001095944.1  selection and upkeep of intraepithelial T-cells protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001095944.1

      Status: VALIDATED

      Source sequence(s)
      AK040383, AL611968, EF494894
      Consensus CDS
      CCDS51268.1
      UniProtKB/Swiss-Prot
      A7TZF0, A7TZF2, Q8BIN0
      Related
      ENSMUSP00000131300.2, ENSMUST00000170945.2
      Conserved Domains (3) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:35 → 140
      IG_like; Immunoglobulin like
      cl11960
      Location:159 → 221
      Ig; Immunoglobulin domain

    2. NM_001348354.1 → NP_001335283.1  selection and upkeep of intraepithelial T-cells protein 3 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AK040383, AL611968, EF494896
      UniProtKB/Swiss-Prot
      A7TZF0
      Conserved Domains (1) summary
      cl11960
      Location:38 → 104
      Ig; Immunoglobulin domain

    3. NM_177578.4 → NP_808246.1  selection and upkeep of intraepithelial T-cells protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_808246.1

      Status: VALIDATED

      Source sequence(s)
      AL611968
      Consensus CDS
      CCDS38838.1
      UniProtKB/Swiss-Prot
      A7TZF0
      Related
      ENSMUSP00000042662.6, ENSMUST00000038455.12
      Conserved Domains (3) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:35 → 140
      IG_like; Immunoglobulin like
      cl11960
      Location:159 → 221
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      112089442..112157665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7TZF0.1 GenPept UniProtKB/Swiss-Prot:A7TZF0

    Gene LinkOut

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