Rnase3 ribonuclease A family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnase3provided by RGD
Official Full Name: ribonuclease A family member 3provided by RGD
Primary source: RGD:621580
See related: EnsemblRapid:ENSRNOG00000063957 AllianceGenome:RGD:621580
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: R1; R7; EAR; ECP; Ear11
Summary: Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Predicted to be involved in chemotaxis and defense response to other organism. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human RNASE3 (ribonuclease A family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 125.0), Spleen (RPKM 68.0) and 2 other tissues See more
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Genomic context

Location:: 15p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26985399..26986269, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24511894..24512764, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28216744..28217614, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ECP induces dose-dependent cell death in both cerebellar granule cells and astrocytes; the effect of ECP action on cell morphology is consistent with apoptosis for both cell types.
Title: Eosinophil-induced neurotoxicity: the role of eosinophil cationic protein/RNase 3.
results demonstrate direct, charge-dependent, & long-lasting sensitizing effect of cationic proteins on pulmonary sensory neurons, may contribute to hyperresponsiveness associated with airway infiltration of eosinophils under pathophysiological conditions
Title: Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteins.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eosinophil cationic protein

Names: EAR-11; RNase 3; eosinophil secondary granule ribonuclease 11; eosinophil-associated ribonuclease; eosinophil-associated, ribonuclease A family, member 11; ribonuclease 1; ribonuclease 3; ribonuclease 7; ribonuclease, RNase A family, 3

NP_620257.1

EC 3.1.27.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.