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    Hyou1 hypoxia up-regulated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192235, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hyou1provided by RGD
    Official Full Name
    hypoxia up-regulated 1provided by RGD
    Primary source
    RGD:621146
    See related
    EnsemblRapid:ENSRNOG00000010944 AllianceGenome:RGD:621146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cab140; Orp150
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway and response to hypoxia. Located in smooth endoplasmic reticulum. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 375.6), Liver (RPKM 349.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hyou1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53602882..53614998)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44706073..44718189)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48699796..48711912)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene solute carrier family 37 member 4 Neighboring gene trafficking protein particle complex subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of endoplasmic reticulum chaperone complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of endoplasmic reticulum chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hypoxia up-regulated protein 1
    Names
    150 kDa oxygen-regulated protein
    ORP-150
    oxygen regulated protein (150kD)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034028.1NP_001029200.1  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_001029200.1

      Status: VALIDATED

      Source sequence(s)
      BC065310, CB691248
      UniProtKB/TrEMBL
      A0A8J8XLC6, F1LN18, Q6P136
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:35700
      HSP70; Hsp70 protein
      pfam06459
      Location:549706
      RR_TM4-6; Ryanodine Receptor TM 4-6
    2. NM_138867.2NP_620222.2  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_620222.2

      Status: VALIDATED

      Source sequence(s)
      BC065310, U41853
      UniProtKB/TrEMBL
      A0A8J8XLC6, F1LN18, Q6P136
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:35700
      HSP70; Hsp70 protein
      pfam06459
      Location:549706
      RR_TM4-6; Ryanodine Receptor TM 4-6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53602882..53614998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242885.4XP_006242947.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006242947.1

      UniProtKB/TrEMBL
      A0A8J8XLC6, F1LN18, Q6P136
      Related
      ENSRNOP00000039172.6, ENSRNOT00000044613.6
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:35700
      HSP70; Hsp70 protein
      pfam06459
      Location:549706
      RR_TM4-6; Ryanodine Receptor TM 4-6
    2. XM_006242884.4XP_006242946.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006242946.1

      UniProtKB/TrEMBL
      A0A8J8XLC6, F1LN18, Q6P136
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      pfam00012
      Location:35700
      HSP70; Hsp70 protein
      pfam06459
      Location:549706
      RR_TM4-6; Ryanodine Receptor TM 4-6