cyn-12 Peptidyl-prolyl cis-trans isomerase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyn-12
Official Full Name: Peptidyl-prolyl cis-trans isomerase
Primary source: WormBase:WBGene00000888
Locus tag: CELE_C34D4.12
See related: AllianceGenome:WB:WBGene00000888
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in mRNA splicing, via spliceosome and protein folding. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 14. Orthologous to human PPIL1 (peptidylprolyl isomerase like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyn-12 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (7132132..7133217, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34D4.12 (e-PCR)
- UniSTS:320863

C34D4.13 (e-PCR)
- UniSTS:320864

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peptidyl-prolyl cis-trans isomerase

NP_001368362.1

Confirmed by transcript evidence

NP_501118.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7132132..7133217 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068717.6 → NP_501118.1 Peptidyl-prolyl cis-trans isomerase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501118.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18445

Conserved Domains (1) summary

cd01922
Location:13 → 159

cyclophilin_SpCYP2_like; cyclophilin_SpCYP2_like: cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent ...
NM_001380307.1 → NP_001368362.1 Peptidyl-prolyl cis-trans isomerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLB6

Conserved Domains (1) summary

cl00197
Location:1 → 26

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...