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    ceh-8 Homeobox domain-containing protein;Homeobox protein ceh-8 [ Caenorhabditis elegans ]

    Gene ID: 191617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-8
    Official Full Name
    Homeobox domain-containing protein;Homeobox protein ceh-8
    Primary source
    WormBase:WBGene00000433
    Locus tag
    CELE_ZK265.4
    See related
    AllianceGenome:WB:WBGene00000433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation. Predicted to be located in nucleus. Is expressed in lateral ganglion and somatic gonad precursor. Human ortholog(s) of this gene implicated in age related macular degeneration 6; cone-rod dystrophy 11; isolated microphthalmia 3; and retinitis pigmentosa. Orthologous to several human genes including RAX2 (retina and anterior neural fold homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (8245505..8250948, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Acyl-coenzyme A diphosphatase FITM2 Neighboring gene Nucleolar protein 16 Neighboring gene Serpentine Receptor, class E (Epsilon)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans. Pujol N, et al. Development, 2000 Aug. PMID 10887091
    2. Caenorhabditis elegans has scores of homoeobox-containing genes. Bürglin TR, et al. Nature, 1989 Sep 21. PMID 2571091
    3. Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts. Kroetz MB, et al. G3 (Bethesda), 2015 Oct 23. PMID 26497144, Free PMC Article
    4. Unique homeobox codes delineate all the neuron classes of C. elegans. Reilly MB, et al. Nature, 2020 Aug. PMID 32814896, Free PMC Article
    5. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pattern specification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Homeobox domain-containing protein;Homeobox protein ceh-8
    NP_001305205.1
    • Confirmed by transcript evidence
    NP_001305206.1
    • Confirmed by transcript evidence
    NP_492246.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8245505..8250948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059845.4 → NP_492246.2  Homeobox protein ceh-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492246.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94398
      Conserved Domains (1) summary
      pfam00046
      Location:64 → 116
      Homeobox; Homeobox domain

    2. NM_001318276.4 → NP_001305205.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XRQ4
      Conserved Domains (1) summary
      pfam00046
      Location:62 → 115
      Homeobox; Homeobox domain

    3. NM_001318277.3 → NP_001305206.1  Homeobox protein ceh-8 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XRV4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94398.3

    Gene LinkOut

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