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    Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [ Mus musculus (house mouse) ]

    Gene ID: 19052, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp2caprovided by MGI
    Official Full Name
    protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprovided by MGI
    Primary source
    MGI:MGI:1321159
    See related
    Ensembl:ENSMUSG00000020349 AllianceGenome:MGI:1321159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP2A
    Summary
    Enables GABA receptor binding activity and protein serine/threonine phosphatase activity. Involved in T cell homeostasis; negative regulation of glycolytic process through fructose-6-phosphate; and regulation of intracellular signal transduction. Acts upstream of or within mesoderm development. Located in chromosome, centromeric region; cytosol; and plasma membrane. Part of protein phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 132.5), CNS E18 (RPKM 128.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppp2ca in Genome Data Viewer
    Location:
    11 B1.3; 11 31.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51989651..52013576)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52098824..52122749)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene STARR-seq mESC enhancer starr_29438 Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene cyclin dependent kinase like 3 Neighboring gene STARR-seq mESC enhancer starr_29439 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51879429-51879612 Neighboring gene STARR-positive B cell enhancer ABC_E8875 Neighboring gene STARR-positive B cell enhancer ABC_E10674 Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061 Neighboring gene olfactory receptor family 2 subfamily Y member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process through fructose-6-phosphate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NLRP3 inflammasome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glycolytic process through fructose-6-phosphate ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein serine/threonine phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Names
    PP2A-alpha
    NP_062284.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019411.4NP_062284.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

      See identical proteins and their annotated locations for NP_062284.1

      Status: VALIDATED

      Source sequence(s)
      AL935177
      Consensus CDS
      CCDS24666.1
      UniProtKB/Swiss-Prot
      O88591, P13353, P63330, Q5SNY5
      UniProtKB/TrEMBL
      Q8BN07
      Related
      ENSMUSP00000020608.3, ENSMUST00000020608.3
      Conserved Domains (1) summary
      cd07415
      Location:9293
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51989651..52013576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)