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    frpr-19 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frpr-19
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00021510
    Locus tag
    CELE_Y41D4A.8
    See related
    AllianceGenome:WB:WBGene00021510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See frpr-19 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (1775181..1781659, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling via the FLP-14/FRPR-19 neuropeptide pathway sustains nociceptive response to repeated noxious stimuli in C. elegans. Marques F, et al. PLoS Genet, 2021 Nov. PMID 34748554, Free PMC Article
    2. The neuropeptidergic connectome of C. elegans. Ripoll-Sánchez L, et al. Neuron, 2023 Nov 15. PMID 37935195, Free PMC Article
    3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signaling via the FLP-14/FRPR-19 neuropeptide pathway sustains nociceptive response to repeated noxious stimuli in C. elegans.
      Title: Signaling via the FLP-14/FRPR-19 neuropeptide pathway sustains nociceptive response to repeated noxious stimuli in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001294552.1
    • Confirmed by transcript evidence
    NP_001370911.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1775181..1781659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307623.5 → NP_001294552.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC84
      Conserved Domains (1) summary
      cd14978
      Location:64 → 363
      7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001383044.2 → NP_001370911.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMM5
      Conserved Domains (1) summary
      cd14978
      Location:64 → 363
      7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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