ndx-4 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ndx-4
Official Full Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Primary source: WormBase:WBGene00003581
Locus tag: CELE_Y37H9A.6
See related: AllianceGenome:WB:WBGene00003581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity and bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Involved in nucleotide metabolic process. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ndx-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003279.8 (13792639..13794152, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDX-4 exhibits both hallmarks of a MutT-type enzyme with an ability to hydrolyze 8-oxodGTP and suppress the Escherichia coli mutT mutator phenotype.NDX-4 contributes to genomic stability in vivo in C. elegans.
Title: Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37H9A.6 (e-PCR)
- UniSTS:318657

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-nucleosyl)-tetraphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in diadenosine tetraphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ribose phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

NP_493413.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13792639..13794152 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061012.7 → NP_493413.1 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493413.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2M7

Conserved Domains (1) summary

cd03428
Location:3 → 133

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...