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    duox-2 NAD(P)H oxidase (H2O2-forming) [ Caenorhabditis elegans ]

    Gene ID: 186188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    duox-2
    Official Full Name
    NAD(P)H oxidase (H2O2-forming)
    Primary source
    WormBase:WBGene00018771
    Locus tag
    CELE_F53G12.3
    See related
    AllianceGenome:WB:WBGene00018771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Predicted to be located in membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to several human genes including DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See duox-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (137845..144565)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Growth-regulating factor;K Homology domain-containing protein Neighboring gene LisH domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Dual oxidase 1 Neighboring gene SSD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. Edens WA, et al. J Cell Biol, 2001 Aug 20. PMID 11514595, Free PMC Article
    2. ROS regulation of RAS and vulva development in Caenorhabditis elegans. Kramer-Drauberg M, et al. PLoS Genet, 2020 Jun. PMID 32544191, Free PMC Article
    3. Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging. Ewald CY. Antioxidants (Basel), 2018 Sep 28. PMID 30274229, Free PMC Article
    4. Caenorhabditis elegans exoskeleton collagen COL-19: an adult-specific marker for collagen modification and assembly, and the analysis of organismal morphology. Thein MC, et al. Dev Dyn, 2003 Mar. PMID 12619137
    5. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide-generating NAD(P)H oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)H oxidase (H2O2-forming)
    NP_490684.1
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      137845..144565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058283.1 → NP_490684.1  NAD(P)H oxidase (H2O2-forming) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01795
      Conserved Domains (5) summary
      cd06186
      Location:1224 → 1408
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41 → 596
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      COG5126
      Location:792 → 895
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam01794
      Location:1041 → 1182
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03098
      Location:39 → 552
      An_peroxidase; Animal haem peroxidase
    Nucleotide Protein
    Heading Accession and Version

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