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    clec-78 C-type LECtin [ Caenorhabditis elegans ]

    Gene ID: 185915, updated on 9-Dec-2024

    Summary

    Official Symbol
    clec-78
    Official Full Name
    C-type LECtin
    Primary source
    WormBase:WBGene00018547
    Locus tag
    CELE_F47C12.2
    See related
    AllianceGenome:WB:WBGene00018547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and serine-type peptidase activity. Involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region and membrane. Is expressed in pharyngeal muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See clec-78 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    26
    Sequence:
    Chromosome: IV; NC_003282.8 (3989102..4014235)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain Neighboring gene pseudo Neighboring gene SET domain-containing protein Neighboring gene CX3C2 protein;Proteolipid protein 2 Neighboring gene Helix-loop-helix protein 30 Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables serine-type peptidase activity  
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in membrane  

    General protein information

    Preferred Names
    C-type LECtin
    NP_500454.2
    • Product from WormBase gene class clec;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3989102..4014235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068053.5NP_500454.2  C-type LECtin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500454.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20531
      Conserved Domains (16) summary
      cd00033
      Location:10371092
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00034
      Location:48179
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00042
      Location:234333
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00179
      Location:806845
      EGF_CA; Calcium-binding EGF-like domain
      smart00231
      Location:12971429
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:340447
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:22442280
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:12881428
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00112
      Location:183217
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00084
      Location:11721232
      Sushi; Sushi repeat (SCR repeat)
      pfam02494
      Location:15401621
      HYR; HYR domain
      pfam07699
      Location:19652012
      GCC2_GCC3; GCC2 and GCC3
      pfam12947
      Location:32963336
      EGF_3; EGF domain
      pfam14670
      Location:9741000
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl03620
      Location:14551539
      DUF5011; Domain of unknown function (DUF5011)
      cl22861
      Location:25582713
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
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